一例产生粒细胞集落刺激因子的胰腺无细胞癌切除病例及文献综述。

IF 0.7 Q4 SURGERY
Norio Kubo, Shigemasa Suzuki, Takahiro Seki, Shunsaku Furuke, Naoki Yagi, Takashi Ooki, Ryusuke Aihara, Akira Mogi, Yuka Yoshida, Kenji Kashiwabara, Yasuo Hosouchi, Ken Shirabe
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引用次数: 0

摘要

背景:各种器官中都有产生粒细胞集落刺激因子(G-CSF)肿瘤的报道,而产生G-CSF的胰腺癌患者的预后尤其令人沮丧。在本报告中,我们介绍了一例产生 G-CSF 的胰腺无细胞癌(ACP),其特点是术后早期复发,生长迅速且不受控制:一名 74 岁的男性因主诉进食后腹部饱胀和疼痛来我院就诊。入院时发现外周血白细胞计数和血清 G-CSF 水平明显升高(分别为 23,770 个/μL 和 251 pg/mL)。腹部计算机断层扫描显示,胰头肿瘤累及肠系膜上静脉。超声引导下细针穿刺病理证实为 ACP。随后,我们进行了保留胃的胰十二指肠次全切除术,同时进行了门静脉重建和部分横结肠切除。术后第 7 天(POD),白细胞计数从 21180/μL降至 8490/μL;此外,计算机断层扫描发现肝转移。因此,患者于 POD 30 开始接受 mFOLFILINOX 化疗。然而,肿瘤迅速恶化,患者于POD 45死亡:结论:产生G-CSF的ACP非常罕见,患者的预后极差。结论:产G-CSF的ACP非常罕见,患者预后极差,需要进行基础研究,以开发针对产G-CSF肿瘤的有效药物,并利用国家数据库进行大规模研究,以开发多学科治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case of resected anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor with literature review.

Background: Granulocyte colony-stimulating factor (G-CSF)-producing tumors have been reported in various organs, and the prognosis of patients with G-CSF-producing pancreatic cancers is particularly dismal. In this report, we present a case of G-CSF-producing anaplastic carcinoma of the pancreas (ACP), characterized by early postoperative recurrence and rapid, uncontrolled growth.

Case presentation: A 74-year-old man presented to our hospital with complaints of abdominal fullness and pain after eating. On admission, it was observed that the peripheral leukocyte counts and serum G-CSF levels were significantly elevated (23,770/µL and 251 pg/mL, respectively). Computed tomography of the abdomen revealed a pancreatic head tumor involving the superior mesenteric vein. Pathologically, ultrasound-guided fine-needle aspiration confirmed ACP. Subsequently, we performed a subtotal stomach-preserving pancreaticoduodenectomy with portal vein reconstruction and partial transverse colon resection. On postoperative day (POD) 7, the leukocyte count decreased from 21,180/μL to 8490/μL; moreover, computed tomography revealed liver metastasis. Therefore, mFOLFILINOX chemotherapy was initiated on POD 30. However, the tumor exhibited rapid progression, and the patient died on POD 45.

Conclusions: G-CSF-producing ACP is rare, and the prognosis of patients is extremely poor. Basic research is required to develop effective drugs against G-CSF-producing tumors, and large-scale studies using national databases are needed to develop multidisciplinary treatment methods.

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