放疗治疗视网膜母细胞瘤引起的视网膜血管增生

IF 0.9 4区 医学 Q4 OPHTHALMOLOGY
Hannah Istre-Wilz, Jared J Ebert, James J Augsburger, Maura Di Nicola, Zelia M Correa, Basil K Williams
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引用次数: 0

摘要

背景和目的:视网膜胶质血管增生(RGVP)是视网膜的一种良性病变,可以是特发性的,也可以是继发于其他疾病的。本研究描述了六名继发性 RGVP 患者的临床特征、治疗方法和预后,这些患者均伴有视网膜母细胞瘤照射后消退的情况,并将其与视网膜母细胞瘤晚期局部复发区分开来:在对1975年至2022年期间在一家眼部肿瘤诊所接受视网膜母细胞瘤评估的550名患者的现有临床记录进行回顾性审查时,发现有6名患者的7只眼睛在已治疗和消退的视网膜母细胞瘤上有继发性RGVP。本文描述了这些患者的临床特征、治疗和结果:结果:RGVP确诊时的中位年龄为20岁。所有的RGVP都与完全消退的视网膜母细胞瘤有关,并且邻近钙化的肿瘤残留物或脉络膜萎缩,这些残留物经过外照射放疗(6只眼睛)或斑块近距离放射治疗(1只眼睛)后仍然存在。病变的最大基底直径在 2.8 至 12 毫米之间,厚度在 1.3 至 4.4 毫米之间,呈球状隆起,伴有局灶性视网膜毛细血管扩张,通常伴有覆盖的视网膜下积液或出血。从最初治疗视网膜母细胞瘤到发现 RGVP 的中位时间为 20 年。治疗是根据病变生长的证据决定的,通常包括激光光凝和玻璃体内抗血管内皮生长因子注射。通过对治疗过的病灶进行随访,所有病灶都至少出现了部分消退,而两个未经治疗的病灶则保持稳定,这让我们对视网膜母细胞瘤的晚期局部复发有了信心:结论:继发性视网膜母细胞瘤偶尔会出现与先前已照射过的视网膜母细胞瘤消退有关的病变。这种病变必须与晚期局部复发的活动性视网膜母细胞瘤区分开来。[眼科手术激光成像视网膜2024;55:XX-XX]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retinal Gliovascular Proliferation Secondary to Retinoblastoma Treated With Radiotherapy.

Background and objective: Retinal gliovascular proliferation (RGVP) is a benign lesion of the retina that can arise idiopathically or secondary to another disease entity. This study describes the clinical features, treatment, and outcomes of six patients with secondary RGVP associated with irradiated, regressed retinoblastoma, and distinguishes it from late local relapse of retinoblastoma.

Patients and methods: In a retrospective review of available clinical records of 550 patients evaluated for retinoblastoma in a single ocular oncology practice between 1975 and 2022, seven eyes of six patients were identified as having secondary RGVP overlying a treated and regressed retinoblastoma. The clinical features, treatment, and outcomes are described.

Results: The median age at RGVP diagnosis was 20 years. All RGVPs were associated with a completely regressed retinoblastoma and in proximity to a calcific tumor residue or chorioretinal atrophy that remained after external beam radiotherapy (six eyes) or plaque brachytherapy (one eye). Lesions were measured between 2.8 to 12 mm in largest basal diameter and 1.3 to 4.4 mm in thickness and described as globular, raised areas with focal retinal telangiectasis often associated with overlying subretinal fluid or hemorrhage. Median time between initial retinoblastoma treatment and detection of RGVP was 20 years. Treatment was decided based on evidence of lesion growth and most often consisted of laser photocoagulation and intravitreal anti-VEGF injection. Through available follow-up of the treated lesions, all exhibited at least partial regression, while two untreated lesions remained stable, reassuring us against late local relapse of retinoblastoma.

Conclusions: Secondary RGVP develops occasionally in association with regressed previously irradiated retinoblastoma. This lesion must be distinguished from late local relapse of active retinoblastoma. [Ophthalmic Surg Lasers Imaging Retina 2024;55:714-720.].

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
89
期刊介绍: OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.
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