椰子油影响蒙古沙鼠肝脏形态生理学中与衰老相关的变化

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Vitor Grigio , Luiz Henrique Alves Guerra , Stella Bicalho Silva , Mariella Bontempo Freitas , Sebastião Roberto Taboga , Patrícia Simone Leite Vilamaior
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引用次数: 0

摘要

衰老会导致肝脏形态生理学发生变化,改变肝细胞形态和器官功能。由于椰子油具有抗氧化和抗炎特性,它已被用作膳食中的一种治疗剂,试图减轻衰老自然引起的肝脏变化。在此,我们评估了衰老过程中食用椰子油对蒙古沙鼠肝脏形态生理学的影响。动物被分为三个实验组:成年对照组(AC)的沙鼠在3月龄时安乐死,老年对照组(OC)的沙鼠在15月龄时安乐死,椰子油组(CO)的沙鼠在12个月内每天摄入0.1毫升椰子油,并在15月龄时安乐死。在衰老过程中长期食用椰子油可防止动物和肝脏增重。然而,其他结果显示,椰子油加剧了衰老的形态生理变化,促进了肝细胞细胞质和细胞核的增加。此外,在 CO 组中还观察到血管、网状纤维、脂滴和脂褐素颗粒的增加。最后,研究结果还表明,椰子油会促进脂质过氧化的增加,表现为 MDA 水平的增加。因此,我们得出结论,椰子油有可能加剧肝脏在衰老过程中发生的形态生理变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Coconut oil affects aging-related changes in Mongolian gerbil liver morphophysiology

Coconut oil affects aging-related changes in Mongolian gerbil liver morphophysiology
Aging causes changes in liver morphophysiology, altering hepatocyte morphology and organ function. Due to its antioxidant and anti-inflammatory properties, coconut oil has been used as a therapeutic agent in diets, in an attempt to attenuate alterations in the liver naturally caused by aging. Herein, we evaluated the effects of coconut oil consumption during aging on Mongolian gerbil liver morphophysiology. The animals were divided into three experimental groups: the gerbils in the Adult Control Group (AC) were euthanized at 3 months of age, the gerbils in the Old Control Group (OC) at 15 months of age, and the gerbils in the Coconut Oil Group (CO) received 0.1 ml/day of coconut oil for 12 months and were euthanized at 15 months of age. Prolonged consumption of coconut oil during aging prevented the animals and the liver from gaining mass. However, the other results showed that coconut oil intensified the morphophysiological alterations of aging, promoting an increase in the hepatocyte cytoplasm and nuclei. In addition, an increase in blood vessels, reticular fibers, lipid droplets, and lipofuscin granules were observed in the CO group. Finally, the results also demonstrated that coconut oil promotes an increase in lipid peroxidation, indicated by an increase in MDA levels. We therefore conclude that coconut oil has the potential to intensify the morphophysiological alterations that occur in the liver during aging.
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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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