膳食炎症指数和膳食总抗氧化能力与桥本氏甲状腺炎的关系:一项病例对照研究。

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Sepideh Alijani, Maliheh Ghadir, Bahram Pourghassem Gargari
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引用次数: 0

摘要

背景:桥本氏甲状腺炎(HT)是一种以活性氧增加为特征的炎症性疾病。富含抗炎和抗氧化特性的饮食可能与降低患桥本氏甲状腺炎的风险有关。本研究旨在调查伊朗成年人的膳食炎症指数(DII)和膳食总抗氧化能力(DTAC)与 HT 之间的关系:该研究是一项基于医院的病例对照研究,共有 230 人参加(115 例病例和 115 例对照)。膳食摄入量通过食物频率问卷(FFQ)进行评估。FFQ 数据用于计算 DII 和 DTAC 分数。人体测量、甲状腺功能和抗体检测均采用标准方法进行评估。在原始模型和调整模型中进行了多变量逻辑回归分析,以确定DII和DTAC得分与高血压之间的关系:参与者的平均年龄为 39.76 ± 9.52 岁。病例组和对照组的平均体重指数分别为(28.03 ± 6.32)和(26.43 ± 5.13)(kg/m2)(P = 0.036)。高密度脂蛋白胆固醇组的 DII 水平更高(P 结论:高密度脂蛋白胆固醇与 DII 的增加无关:DII 的增加与 HT 风险的增加无关,而 DTAC 可显著降低 HT 风险。抗炎和抗氧化饮食可有效改善甲状腺功能。这些结论应在更多的前瞻性研究中得到证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association between dietary inflammatory index and dietary total antioxidant capacity and Hashimoto's thyroiditis: a case-control study.

Background: Hashimoto's thyroiditis (HT) is an inflammatory disease characterized by increased reactive oxygen species. Diets rich in anti-inflammatory and antioxidant properties may be linked to a reduced risk of developing HT. The aim of this study was to investigate the association between the dietary inflammatory index (DII) and dietary total antioxidant capacity (DTAC) with HT in Iranian adults.

Methods: The study was a hospital-based case-control study conducted on 230 participants (115 cases and 115 controls). Dietary intake was assessed using a food frequency questionnaire (FFQ). The FFQ data were used to calculate DII and DTAC scores. Anthropometric measurements, thyroid function, and antibody tests were evaluated using standard methods. Multivariable logistic regression analysis was performed in both raw and adjusted models to determine the association between DII and DTAC scores with HT.

Results: The average age of the participants was 39.76 ± 9.52 years. The mean body mass index in the case and control groups was 28.03 ± 6.32 and 26.43 ± 5.13 (kg/m2), respectively (P = 0.036). In the HT group, the DII level was higher (P < 0.001) and the DTAC level was lower than those in the healthy group (P = 0.047). In the multivariable logistic regression model, after adjusting for confounding factors, subjects in the last tertile of DII had a nonsignificantly higher HT risk than those in the first tertile (OR = 1.75; 95% CI = 0.83-3.65; P = 0.130). Regarding DTAC, the subjects in the last tertile of DTAC had a significantly decreased risk of HT (OR = 0.47; 95% CI = 0.23-0.98; P = 0.043) compared to those in the first tertile. The DII had a positive correlation with anti-thyroid peroxidase antibody (anti-TPO), thyroglobulin antibodies (TG-Ab) and thyroid-stimulating hormone, while DTAC had a negative correlation with anti-TPO and TG-Ab (P < 0.050).

Conclusion: The increase in DII is not associated with an increase in the risk of HT, while DTAC can significantly reduce its risk. Having an anti-inflammatory and antioxidative diet can be effective in improving thyroid function. These conclusions should be confirmed in additional prospective studies.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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