Au(III)/TPPMS 催化水中失活 N-烷基苯胺的 Friedel-Crafts 苄基化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-02 DOI:10.1039/d4ob01234h

Hidemasa Hikawa , Akane Fukuda , Kazuma Kondo , Taku Nakayama , Tomokatsu Enda , Shoko Kikkawa , Isao Azumaya

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引用次数: 0

摘要

由于芳香环的电子密度降低，对电子失活苯胺（包括具有强吸电子 NO2、CN 或 CO2H 基团的苯胺）进行 Friedel-Crafts 反应具有挑战性。在此，我们展示了 Au(III)/TPPMS 催化的失活苯胺在水中的 Friedel-Crafts 苄基化反应。该反应操作简单，底物范围广，具有很高的区域选择性，可快速获得 2-苄基苯胺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Au(iii)/TPPMS-catalyzed Friedel–Crafts benzylation of deactivated N-alkylanilines in water†

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Au(iii)/TPPMS-catalyzed Friedel–Crafts benzylation of deactivated N-alkylanilines in water†

The Friedel–Crafts reaction of electronically deactivated anilines including those with strong electron-withdrawing NO₂, CN or CO₂H groups is challenging due to the reduced electron density of the aromatic ring. Here, we demonstrate the Au(iii)/TPPMS-catalyzed Friedel–Crafts benzylation of deactivated anilines in water. This reaction exhibits operational simplicity and a broad substrate scope with high regioselectivity, enabling rapid access to 2-benzylanilines.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.