心力衰竭患者血清支链氨基酸和海洋欧米加-3 脂肪酸水平与运动不耐受的关系

Q3 Nursing
Takeshi Sota , Yoshiharu Kinugasa , Natsuko Nakayama , Kensuke Nakamura , Masayuki Hirai , Masahiko Kato , Taisuke Ono , Masashige Takahashi , Hisashi Matsuo , Ryuichi Matsukawa , Ichiro Yoshida , Shigeo Kakinoki , Kazuya Yonezawa , Yoshihiro Himura , Takashi Yokota , Kazuhiro Yamamoto , Miyuki Tsuchihashi-Makaya , Shintaro Kinugawa
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引用次数: 0

摘要

背景& 目的支链氨基酸(BCAAs)和海洋欧米伽-3 脂肪酸二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)可预防老年人体力衰退。然而,它们对心力衰竭(HF)患者身体功能的综合影响尚不清楚。本研究旨在调查 BCAAs 和 EPA/DHA 与心力衰竭患者运动耐量的关系。结果 6 分钟步行距离定量值较低的女性患者多于 6 分钟步行距离定量值较高的患者。与 6 分钟步行距离较长的患者相比,6 分钟步行距离较短的患者年龄较大,腿围较小,B 型钠尿肽浓度较高,BCAA 和 EPA/DHA 水平较低(所有 P 均为 0.05)。6-MWD较短的患者饮食结构失衡,油鱼、豆制品和蔬菜摄入量较低。同时,他们估计的营养摄入量中饱和脂肪酸和蔗糖含量较高,而多不饱和脂肪酸和膳食纤维含量较低(均为 P < 0.05)。根据多变量分析,低 EPA/DHA 浓度(每减少 50 μg/mL)[几率比,95% 置信区间:1.479(1.025-2.137)]、低膳食纤维摄入量(每减少 1 克/1000 千卡)[1.524(1.098-2.119)]和高蔗糖摄入量(每增加 1 克/1000 千卡热量)[1.170(1.040-1.310)]与 6-MWD 短(6-MWD 的最低四分位数,<350m)独立相关(P <0.05)。当评估 EPA/DHA 和 BCAA 对 6-MWD 的影响时,EPA/DHA 浓度低对 6-MWD 短的影响在 BCAA 水平低的患者中更为明显(交互作用 P < 0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Associations of serum branched-chain amino acid and marine omega-3 fatty acid levels with exercise intolerance in heart failure patients

Associations of serum branched-chain amino acid and marine omega-3 fatty acid levels with exercise intolerance in heart failure patients

Background & Aims

Branched-chain amino acids (BCAAs), and the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent physical decline in older people. However, their combined effect on physical function in heart failure (HF) is unclear. This study aimed to investigate the association of BCAAs and EPA/DHA with exercise tolerance in people with HF.

Methods

In total, 124 patients with HF were prospectively enrolled, and their serum BCAA and EPA/DHA levels, dietary pattern, and 6-minute walking distance (6-MWD) were assessed.

Results

Lower 6-MWD quantiles contained more female patients than higher 6-MWD quantiles. Patients with a shorter 6-MWD were older and had a smaller leg circumference, higher B-type natriuretic peptide concentrations, and lower BCAA and EPA/DHA levels than those with longer 6-MWD (all P < 0.05). Patients with a shorter 6-MWD had an imbalanced dietary pattern with low intakes of oily fish, soy products, and vegetables. Meanwhile, their estimated nutrient intakes were high in saturated fatty acids and sucrose and low in polyunsaturated fatty acids and dietary fiber (all P < 0.05). According to multivariate analysis, low EPA/DHA concentrations (per 50 μg/mL decrease) [odds ratio, 95% confidence interval: 1.479 (1.025–2.137)], low dietary fiber intake (per 1 g/1000kcal decrease) [1.524 (1.098–2.119)], and high sucrose intake (per 1 g/1000kcal increase) [1.170 (1.040–1.310)] were independently associated with short 6-MWD (the lowest quantile of 6-MWD, <350m) (P < 0.05). When the effect of EPA/DHA and BCAAs on 6-MWD was assessed, the impact of low EPA/DHA concentrations on short 6-MWD was stronger in patients with low BCAA levels (P < 0.05 for interaction).

Conclusions

Patients with HF and impaired exercise tolerance consumed an imbalanced diet; the combination of low BCAA and low EPA/DHA concentrations was associated with exercise intolerance in these patients.

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来源期刊
Clinical Nutrition Open Science
Clinical Nutrition Open Science Nursing-Nutrition and Dietetics
CiteScore
2.20
自引率
0.00%
发文量
55
审稿时长
18 weeks
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