用于糖尿病伤口治疗的核酸递送策略的进展

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM
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引用次数: 0

摘要

近年来,糖尿病伤口的发病率大幅上升,由于容易感染和延迟愈合,给医疗带来了巨大挑战。这些伤口不仅会增加死亡率,还会导致截肢和严重的行动不便。为解决这一问题,将基因、生长因子、蛋白质、肽、干细胞和外泌体等生物活性分子转化为靶向基因疗法已成为研究人员的首选策略。此外,光热疗法(PTT)、核酸和基因疗法与三维打印技术和逐层自组装(LBL)方法的结合,也为糖尿病伤口治疗带来了希望。小干扰 RNA(siRNA)的有效传递依赖于基因载体。本综述深入探讨了糖尿病伤口的病理生理特征,包括血管生成减少、活性氧水平升高和免疫功能受损。报告进一步探讨了核酸递送、靶向基因治疗、先进的药物递送系统、逐层递送(LBL)技术、伤口负压疗法(NPWT)、3D 打印、高压氧疗法以及正在进行的临床试验等方面的进展。通过整合最新的研究成果,本综述介绍了旨在加强糖尿病伤口多方面管理的创新策略,从而为提高未来的治疗效果铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advances in nucleic acid delivery strategies for diabetic wound therapy

Advances in nucleic acid delivery strategies for diabetic wound therapy

In recent years, the prevalence of diabetic wounds has significantly increased, posing a substantial medical challenge due to their propensity for infection and delayed healing. These wounds not only increase mortality rates but also lead to amputations and severe mobility issues. To address this, advancements in bioactive molecules such as genes, growth factors, proteins, peptides, stem cells, and exosomes into targeted gene therapies have emerged as a preferred strategy among researchers. Additionally, the integration of photothermal therapy (PTT), nucleic acid, and gene therapy, along with 3D printing technology and the layer-by-layer (LBL) self-assembly approach, shows promise in diabetic wound treatment. Effective delivery of small interfering RNA (siRNA) relies on gene vectors. This review provides an in-depth exploration of the pathophysiological characteristics observed in diabetic wounds, encompassing diminished angiogenesis, heightened levels of reactive oxygen species, and impaired immune function. It further examines advancements in nucleic acid delivery, targeted gene therapy, advanced drug delivery systems, layer-by-layer (LBL) techniques, negative pressure wound therapy (NPWT), 3D printing, hyperbaric oxygen therapy, and ongoing clinical trials. Through the integration of recent research insights, this review presents innovative strategies aimed at augmenting the multifaceted management of diabetic wounds, thus paving the way for enhanced therapeutic outcomes in the future.

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CiteScore
6.10
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发文量
24
审稿时长
16 weeks
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