通过分子内酰化合成吡咯并[1,2-a]喹啉和吡咯并[1,2-b]异喹啉衍生物

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-08-30 DOI:10.1016/j.tet.2024.134224

引用次数: 0

摘要

本研究开发了一种甲磺酸介导的分子内酰化方法，用于合成吡咯并[1,2-a]喹啉和异构吡咯并[1,2-b]异喹啉框架。反应在常温下进行，无需路易斯酸催化剂。产品收率一般都很高，甚至非常高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of pyrrolo[1,2-a]quinoline and pyrrolo[1,2-b]isoquinoline derivatives via intramolecular acylation

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Synthesis of pyrrolo[1,2-a]quinoline and pyrrolo[1,2-b]isoquinoline derivatives via intramolecular acylation

A methanesulfonic acid mediated intramolecular acylation approach for the synthesis of pyrrolo[1,2-a]quinoline and the isomeric pyrrolo[1,2-b]isoquinoline frameworks has been developed. The reaction is carried out at ambient temperature and no Lewis acid catalyst is required. The product yields are generally good to excellent.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.