回顾与肠道病毒相关的手足口病:预防策略和建立全球肠道病毒监测网络的必要性。

IF 4.9 4区 医学 Q1 PARASITOLOGY
Chien-Yuan Huang, Shih-Bin Su, Kow-Tong Chen
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引用次数: 0

摘要

与肠道病毒(EV)相关的手足口病(HFMD)是全球范围内一个重要的公共卫生问题,通常发生在五岁或五岁以下的儿童身上。大多数手足口病病例的主要病原体是肠道病毒,它们属于皮科病毒科。EV 相关手足口病的典型临床表现是发热,伴有粘膜疱疹、口腔溃疡和手足皮疹。大多数手足口病病例可自行缓解,但也有一部分病例会发展为严重的神经系统和心肺并发症,甚至致命。在过去二十年中,与 EV 相关的手足口病受到了广泛关注。在这篇综述中,我们整理了已发表的论文,并提供了有关 EV 相关手足口病的流行病学、发病机制、监测和疫苗开发的最新信息。在全球范围内,EV 相关性手足口病的影响与日俱增。开发有效的疫苗已成为在没有适当治疗的情况下预防 EV 感染的当务之急。与此同时,新出现的 EV 感染(包括 EV-D68、EV-A71、柯萨奇病毒和埃可病毒)也在增加,这凸显了在全球范围内建立 EV 感染警惕性监测系统的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review of enterovirus-associated hand-foot and mouth disease: preventive strategies and the need for a global enterovirus surveillance network.

Enterovirus (EV)-associated hand, foot, and mouth disease (HFMD) is a significant public health issue worldwide, commonly occurring in children five years of age or younger. The leading causes of most HFMD cases are EVs, which are members of the Picornaviridae family. The typical clinical manifestations of EV-associated HFMD are febrile presentations with mucosal herpangina, oral ulcerations, and skin rashes on the hands and feet. The majority of HFMD cases resolve without consequence; however, a subset progresses to severe neurological and cardiopulmonary complications, which can be fatal. In the past two decades, EV-associated HFMD has received significant attention. In this review, we organize published papers and provide updates on epidemiology, pathogenesis, surveillance, and vaccine developments for EV-associated HFMD. The impact of EV-associated HFMD is increasing globally. Developing efficacious vaccines has become a priority for preventing EV infections without adequate treatment. Simultaneously, emerging EV infections (including EV-D68, EV-A71, Coxsackieviruses, and echoviruses) are increasing, highlighting the need to create a vigilant surveillance system for EV infections worldwide.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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