头颈部淋巴水肿--我们的现状和未来。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI:10.1097/SCS.0000000000010505
Ruby R Taylor, Sonia K Pandey, Taylor Smartz, Wei F Chen, Seth R Thaller
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引用次数: 0

摘要

淋巴手术在治疗四肢淋巴水肿方面取得了巨大进步。然而,包括头颈部在内的其他部位的淋巴水肿却一直被忽视。最近发现的脑部淋巴系统以及颅内和颅旁淋巴系统之间的交流引起了人们对头颈部淋巴管的关注。头颈部淋巴水肿可由淋巴系统的固有异常(原发性)或意外或先天性淋巴管损伤(继发性)引起。头颈部有庞大的淋巴组织网。肿瘤直接浸润、肿瘤和周围癌组织的手术切除和/或放疗都可能影响淋巴组织。在面部美容手术前对患者进行适当的筛查和咨询,可以避免术后淋巴水肿的困扰。头颈部淋巴水肿(HNL)的发展可导致慢性炎症、纤维硬化和纤维脂肪沉积,造成永久性畸形和残疾。患者可能会出现功能障碍,包括皮肤改变、疼痛、活动范围受限、挛缩、吞咽困难、构音障碍、呼吸困难和肢体瘫痪,所有这些都会导致生活质量下降。尽管存在这些已知的残疾,但由于人们对 HNL 缺乏认识,也缺乏可用于测量内部或外部肿胀的工具,因此 HNL 的诊断率很低。作者的文章全面回顾了目前的诊断方法和管理策略,以及未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lymphedema of the Head and Neck-Where Do We Stand and Where We Are Headed.

Great advancements have been made in the management of lymphedema of the extremities with lymphatic surgery. However, lymphedema of other regions, including head and neck, has remained neglected. Recent discovery of lymphatic system in the brain and the communication between intracranial and paracranial lymphatic systems has drawn attention to the head and neck lymphatics. Lymphedema of the head and neck region can result from inherent abnormality of the lymphatic system (primary) or be caused by accidental or iatrogenic injury to lymphatics (secondary). The head and neck contain a large network of lymphatic tissue. They may be affected by direct tumor infiltration, surgical resection of tumors and surrounding cancer tissue, and/or radiotherapy. Proper screening and counseling of patients before facial aesthetic procedures may avoid managing the distress of lymphedema postprocedure. Progression of head and neck lymphedema (HNL) can lead to chronic inflammatory, fibrosclerotic, and fibrofatty deposition, resulting in permanent deformity and disability. Patients may experience functional impairment, including skin changes, pain, range of motion limitations, contracture, dysphagia, dysarthria, dyspnea, and trismus, all leading to reduced quality of life. Despite these known disabilities, HNL is underdiagnosed due to a lack of awareness about this entity and of tools available for measuring internal or external swelling. The authors' article comprehensively reviews the current diagnostic methods and management strategies and what lies ahead.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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