Dana Danino, Yoav Kalron, Jeffrey Haspel, Guy Hazan
{"title":"水痘疫苗有效性的昼夜节律。","authors":"Dana Danino, Yoav Kalron, Jeffrey Haspel, Guy Hazan","doi":"10.1172/jci.insight.184452","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Immune processes are influenced by circadian rhythms. We evaluate the association between varicella vaccine administration time-of-day and vaccine effectiveness.</p><p><strong>Methods: </strong>A national cohort, children < 6 years were enrolled between January 2002 to December 2023. We compared children vaccinated during morning (7:00-10:59), late-morning to afternoon (11:00-15:59), or evening hours (16:00-19:59). A Cox proportional-hazards regression model was used to adjust for ethnicity, sex, and comorbidities. The first varicella infection occurring at least 14 days after vaccination, or a second dose administration were treated as a terminal event.</p><p><strong>Results: </strong>4,501 (1.8%), of 251,141 vaccinated children, experienced breakthrough infections. Infection rates differed based on vaccination time, with the lowest rates associated with late-morning to afternoon (11:00-15:59), HR 0.88, 95% CI 0.82-0.95, P < 0.001, and the highest rates with evening vaccination (16:00-19:59), HR 1.41, 95% CI 1.32-1.52, P < 0.001. Vaccination timing remained significant after adjustment for ethnicity, sex, and comorbidities. The association between immunization time and infection risk followed a sinusoidal pattern, consistent with a diurnal rhythm in vaccine effectiveness.</p><p><strong>Conclusions: </strong>We report a significant association between the time of varicella vaccination and its clinical effectiveness. Similar association was observed with the COVID-19 vaccine, providing proof of concept consistent with a diurnal rhythm in vaccine effectiveness.</p>","PeriodicalId":14722,"journal":{"name":"JCI insight","volume":null,"pages":null},"PeriodicalIF":6.3000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diurnal rhythms in varicella vaccine effectiveness.\",\"authors\":\"Dana Danino, Yoav Kalron, Jeffrey Haspel, Guy Hazan\",\"doi\":\"10.1172/jci.insight.184452\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Immune processes are influenced by circadian rhythms. We evaluate the association between varicella vaccine administration time-of-day and vaccine effectiveness.</p><p><strong>Methods: </strong>A national cohort, children < 6 years were enrolled between January 2002 to December 2023. We compared children vaccinated during morning (7:00-10:59), late-morning to afternoon (11:00-15:59), or evening hours (16:00-19:59). A Cox proportional-hazards regression model was used to adjust for ethnicity, sex, and comorbidities. The first varicella infection occurring at least 14 days after vaccination, or a second dose administration were treated as a terminal event.</p><p><strong>Results: </strong>4,501 (1.8%), of 251,141 vaccinated children, experienced breakthrough infections. Infection rates differed based on vaccination time, with the lowest rates associated with late-morning to afternoon (11:00-15:59), HR 0.88, 95% CI 0.82-0.95, P < 0.001, and the highest rates with evening vaccination (16:00-19:59), HR 1.41, 95% CI 1.32-1.52, P < 0.001. Vaccination timing remained significant after adjustment for ethnicity, sex, and comorbidities. The association between immunization time and infection risk followed a sinusoidal pattern, consistent with a diurnal rhythm in vaccine effectiveness.</p><p><strong>Conclusions: </strong>We report a significant association between the time of varicella vaccination and its clinical effectiveness. Similar association was observed with the COVID-19 vaccine, providing proof of concept consistent with a diurnal rhythm in vaccine effectiveness.</p>\",\"PeriodicalId\":14722,\"journal\":{\"name\":\"JCI insight\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.3000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JCI insight\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1172/jci.insight.184452\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JCI insight","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1172/jci.insight.184452","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Diurnal rhythms in varicella vaccine effectiveness.
Background: Immune processes are influenced by circadian rhythms. We evaluate the association between varicella vaccine administration time-of-day and vaccine effectiveness.
Methods: A national cohort, children < 6 years were enrolled between January 2002 to December 2023. We compared children vaccinated during morning (7:00-10:59), late-morning to afternoon (11:00-15:59), or evening hours (16:00-19:59). A Cox proportional-hazards regression model was used to adjust for ethnicity, sex, and comorbidities. The first varicella infection occurring at least 14 days after vaccination, or a second dose administration were treated as a terminal event.
Results: 4,501 (1.8%), of 251,141 vaccinated children, experienced breakthrough infections. Infection rates differed based on vaccination time, with the lowest rates associated with late-morning to afternoon (11:00-15:59), HR 0.88, 95% CI 0.82-0.95, P < 0.001, and the highest rates with evening vaccination (16:00-19:59), HR 1.41, 95% CI 1.32-1.52, P < 0.001. Vaccination timing remained significant after adjustment for ethnicity, sex, and comorbidities. The association between immunization time and infection risk followed a sinusoidal pattern, consistent with a diurnal rhythm in vaccine effectiveness.
Conclusions: We report a significant association between the time of varicella vaccination and its clinical effectiveness. Similar association was observed with the COVID-19 vaccine, providing proof of concept consistent with a diurnal rhythm in vaccine effectiveness.
期刊介绍:
JCI Insight is a Gold Open Access journal with a 2022 Impact Factor of 8.0. It publishes high-quality studies in various biomedical specialties, such as autoimmunity, gastroenterology, immunology, metabolism, nephrology, neuroscience, oncology, pulmonology, and vascular biology. The journal focuses on clinically relevant basic and translational research that contributes to the understanding of disease biology and treatment. JCI Insight is self-published by the American Society for Clinical Investigation (ASCI), a nonprofit honor organization of physician-scientists founded in 1908, and it helps fulfill the ASCI's mission to advance medical science through the publication of clinically relevant research reports.