Rebeca Bandeira de Melo Cavalcante, Lenora Maria Camarate Silveira Martins Leão, Ana Beatriz Winter Tavares, Karynne Grutter Lopes, Luiz Guilherme Kraemer-Aguiar
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Hormonal/metabolic profiles, inflammatory biomarkers [tumor necrosis factor-alpha (TNF-α and interleukin-6 (IL-6)], anthropometry (waist circumference, waist-to-hip ratio, lipid accumulation product [LAP], visceral adiposity index [VAI]), and body composition assessed through dual-energy X-ray absorptiometry were assessed. The PCOS group exhibited significantly higher androgen levels and markers of IR. However, levels of TNF-α and IL-6 were comparable between the groups. Despite having similar total body fat mass (FM), the PCOS group had excessive central fat, including increased truncal FM and visceral adipose tissue (VAT). In PCOS, androgens were not associated with body fat or its distribution. IL-6 was positively correlated with total and truncal FM, while insulinemia and the homeostatic model assessment for IR were positively associated with VAT, as well as with total and truncal FM. Although anthropometric measurements and indices were positively associated with DXA-derived central FM parameters, our data suggest that LAP is the most effective tool for assessing central fat deposition and metabolic dysfunction in the PCOS patients studied herein. 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引用次数: 0
摘要
多囊卵巢综合征(PCOS)的高心脏代谢风险可能与中央脂肪堆积有关。这项研究比较了患有多囊卵巢综合症的女性与体重指数匹配的对照组之间的脂肪分布情况。研究还试图确定胰岛素抵抗(IR)、雄激素或炎症标志物是否与多囊卵巢综合症患者的身体成分参数相关。研究共纳入了 35 名患有多囊卵巢综合症的女性和 37 名年龄在 18-40 岁之间的对照组女性。研究人员评估了荷尔蒙/代谢概况、炎症生物标志物[肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)]、人体测量(腰围、腰臀比、脂质堆积产物[LAP]、内脏脂肪指数[VAI])以及通过双能 X 射线吸收测定法评估的身体成分。多囊卵巢综合征组的雄激素水平和内分泌失调标志物明显较高。不过,两组之间的 TNF-α 和 IL-6 水平相当。尽管多囊卵巢综合征组的总脂肪量(FM)相似,但其中央脂肪过多,包括躯干脂肪量和内脏脂肪组织(VAT)增加。在多囊卵巢综合症患者中,雄激素与体脂及其分布无关。IL-6与总FM和截干FM呈正相关,而胰岛素血症和内分泌平衡模型评估与VAT以及总FM和截干FM呈正相关。虽然人体测量和指数与 DXA 导出的中心 FM 参数呈正相关,但我们的数据表明,LAP 是评估本研究中多囊卵巢综合征患者中心脂肪沉积和代谢功能障碍的最有效工具。此外,在该人群中,IR(而非雄激素或促炎细胞因子)与腹部肥胖的关系更为密切。
Fat Distribution and its Correlation with Insulin Resistance, Androgen Markers, and Proinflammatory Cytokines in Polycystic Ovary Syndrome.
The high cardiometabolic risk associated with polycystic ovary syndrome (PCOS) may be linked to central fat accumulation. This study compared fat distribution between women with PCOS and controls matched by body mass index. It also sought to determine if insulin resistance (IR), androgens, or inflammatory markers correlate with body composition parameters in PCOS patients. In total, thirty-five women with PCOS and 37 controls, aged 18-40 years, were included. Hormonal/metabolic profiles, inflammatory biomarkers [tumor necrosis factor-alpha (TNF-α and interleukin-6 (IL-6)], anthropometry (waist circumference, waist-to-hip ratio, lipid accumulation product [LAP], visceral adiposity index [VAI]), and body composition assessed through dual-energy X-ray absorptiometry were assessed. The PCOS group exhibited significantly higher androgen levels and markers of IR. However, levels of TNF-α and IL-6 were comparable between the groups. Despite having similar total body fat mass (FM), the PCOS group had excessive central fat, including increased truncal FM and visceral adipose tissue (VAT). In PCOS, androgens were not associated with body fat or its distribution. IL-6 was positively correlated with total and truncal FM, while insulinemia and the homeostatic model assessment for IR were positively associated with VAT, as well as with total and truncal FM. Although anthropometric measurements and indices were positively associated with DXA-derived central FM parameters, our data suggest that LAP is the most effective tool for assessing central fat deposition and metabolic dysfunction in the PCOS patients studied herein. Furthermore, in this population, IR, rather than androgens or proinflammatory cytokines, is more closely associated with abdominal obesity.
期刊介绍:
Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics.
Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens.
Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.