在水介质中以 Ag 催化交叉脱氢偶联合成 1,4-二氧杂环-2-基取代的喹唑啉杂环。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-09-25 DOI:10.1039/d4ob01188k

Xixian Liu , Dayu Xie , Qin Yang , Zhibin Song , Yang Fu , Yiyuan Peng

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引用次数: 0

摘要

我们在此开发了一种在温和条件下构建 2-或 4-（1,4-二氧杂环-2-基）取代喹唑啉的有效方法。报告采用银-K2S2O8 催化喹唑啉类化合物和 1,4-二氧六环之间的直接 CDC 反应，合成了一系列 2-或 4-（1,4-二氧六环-2-基）取代的喹唑啉杂化物。该反应在温和的条件下于水中顺利进行，并显示出广泛的底物范围和良好的官能团兼容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ag-Catalyzed cross-dehydrogenative-coupling for the synthesis of 1,4-dioxan-2-yl substituted quinazoline hybrids in an aqueous medium†

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Ag-Catalyzed cross-dehydrogenative-coupling for the synthesis of 1,4-dioxan-2-yl substituted quinazoline hybrids in an aqueous medium†

We herein developed an effective approach for the construction of 2- or 4-(1,4-dioxan-2-yl) substituted quinazolines under mild conditions. A silver–K₂S₂O₈ catalyzed direct CDC reaction between quinazolines and 1,4-dioxane for the synthesis of a series of 2- or 4-(1,4-dioxan-2-yl) substituted quinazoline hybrids is reported. The reaction proceeded well in water under mild conditions and showed a broad substrate scope and good functional group compatibility.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.