基因-代谢物联系标志着储存的红细胞质量

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-09-03 DOI:10.1016/j.cmet.2024.08.004

Changhan Chen, Wuping Liu, Yang Xia

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引用次数: 0

摘要

长期以来，输注红细胞（RBC）一直是治疗多种疾病的基石，但在影响 RBC 储存质量和输注效果的生物和遗传因素之间还存在知识空白。在本期《细胞代谢》杂志上，Nemkov 等人介绍了一种多组学方法，用于识别新鲜和储存的 RBC 中的基因代谢物关联。这些发现为确定储存红细胞的质量、改善其储存和输血效果提供了潜在的策略。

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Gene-metabolite linkage marks stored red blood cell quality

Red blood cell (RBC) transfusion has long been the cornerstone of treatment for multiple diseases, but there is a knowledge gap between biological and genetic factors impacting RBC storage quality and transfusion efficacy. In this issue of Cell Metabolism, Nemkov et al. present a multiomics approach to identify gene-metabolite associations in fresh and stored RBCs. These findings provide potential strategies to mark the quality of stored RBCs and improve their storage and transfusion performance.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.