通过抑制炎症对抗 "IL-11"：健康与长寿战略

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2024-09-03 DOI:10.1016/j.cmet.2024.08.003

Hee-Hoon Kim, Vishwa Deep Dixit

引用次数: 0

摘要

机体衰老涉及几种标志性途径，包括慢性炎症和代谢功能障碍。然而，人们对与年龄有关的炎症的起源还不甚了解。最近发表在《自然》1 上的一项研究显示，Widjaja 等人阻断了与年龄相关的 IL-11 的增加，从而恢复了小鼠的免疫代谢平衡，延长了小鼠的健康和寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity

Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature,¹ Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.