通过抑制炎症对抗 "IL-11"：健康与长寿战略

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-09-03 DOI:10.1016/j.cmet.2024.08.003

Hee-Hoon Kim, Vishwa Deep Dixit

引用次数: 0

摘要

机体衰老涉及几种标志性途径，包括慢性炎症和代谢功能障碍。然而，人们对与年龄有关的炎症的起源还不甚了解。最近发表在《自然》1 上的一项研究显示，Widjaja 等人阻断了与年龄相关的 IL-11 的增加，从而恢复了小鼠的免疫代谢平衡，延长了小鼠的健康和寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity

Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature,¹ Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.