评估动脉粥样硬化性心血管疾病患者的脂蛋白 (a) 水平:土耳其单中心经验。

Barış Güngör, Barış Şimşek, Tufan Çınar, Melih Öz, Gökçem Ayan Bayraktar, Duygu İnan, Recep Hacı, Yusuf Oflu, Müjgan Mihmanli, Can Yücel Karabay
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引用次数: 0

摘要

研究目的本研究旨在评估脂蛋白 (a) [Lp(a)] 水平升高对动脉粥样硬化性心血管疾病(ASCVD)患者残余风险的潜在影响。考虑到约 90% 的脂蛋白(a)水平是由基因决定的,而且可能因地区而异,我们对土耳其人群中的 ASCVD 患者队列中的脂蛋白(a)水平进行了评估,目前这方面的数据还很有限:我们对一个中心收集的被诊断为 ASCVD 患者的数据和脂蛋白(a)测量结果进行了回顾性分析:分析包括连续 1193 人的脂蛋白(a)水平。脂蛋白(a)水平的平均值为 28.2 mg/dL,中位数为 16 mg/dL,四分位距(IQR)从第 25 百分位数到第 75 百分位数为 7 mg/dL 到 39 mg/dL。记录的最高脂蛋白(a)水平为 326 毫克/分升。病例中,18.7%的患者脂蛋白(a)水平≥50 mg/dL,10.8%的患者脂蛋白(a)水平≥70 mg/dL,5.8%的患者脂蛋白(a)水平≥90 mg/dL。低密度脂蛋白胆固醇(LDL-C)和总胆固醇(TC)的平均水平分别为 132 ± 47 mg/dL 和 212 ± 54 mg/dL。女性的脂蛋白(a)水平明显高于男性。此外,脂蛋白(a)水平≥ 90 mg/dL 的女性比例高于男性(11.4% 对 1.4%;P < 0.01)。此外,还观察到脂蛋白(a)水平与总胆固醇(r = 0.075,P = 0.01)和低密度脂蛋白胆固醇(r = 0.106,P < 0.01)之间存在适度但显著的相关性:本研究显示,在急性心血管疾病患者中,女性和他汀类药物使用者的脂蛋白(a)浓度较高,并发现脂蛋白(a)水平与总胆固醇和低密度脂蛋白胆固醇之间存在微弱但显著的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Lipoprotein (a) Levels in Patients with Atherosclerotic Cardiovascular Disease: Single Center Experience from Türkiye.

Objective: This study aims to evaluate the role of elevated lipoprotein (a) [Lp(a)] levels as a potential contributor to residual risk in individuals with atherosclerotic cardiovascular disease (ASCVD). Considering that approximately 90% of Lp(a) levels are genetically determined and can vary regionally, we assessed Lp(a) levels in a cohort of ASCVD patients from the Turkish population, where data is currently limited.

Methods: We conducted a retrospective analysis of data and Lp(a) measurements collected from individuals diagnosed with ASCVD at a single center.

Results: The analysis included Lp(a) levels of 1193 consecutive individuals. The mean Lp(a) level was 28.2 mg/dL, with a median of 16 mg/dL and an interquartile range (IQR) from the 25th to the 75th percentile, 7 mg/dL to 39 mg/dL. The highest recorded Lp(a) level was 326 mg/dL. Among the cases, 18.7% exhibited Lp(a) levels ≥ 50 mg/dL, 10.8% had levels ≥ 70 mg/dL, and 5.8% had levels ≥ 90 mg/dL. The mean levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were 132 ± 47 mg/dL and 212 ± 54 mg/dL, respectively. Lp(a) levels were significantly higher in females compared to males. Furthermore, the proportion of females with Lp(a) levels ≥ 90 mg/dL was higher than in males (11.4% vs. 1.4%; P < 0.01). Additionally, a modest but significant correlation was observed between Lp(a) levels and TC (r = 0.075, P = 0.01) as well as LDL-C (r = 0.106, P < 0.01).

Conclusion: This study revealed that Lp(a) concentrations were higher in women and statin users among ASCVD patients and identified a weak but significant correlation between Lp(a) levels and both TC and LDL-C.

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