LncRNA 51A：评估职业暴露于铝的工人认知能力下降情况的有望诊断生物标志物。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-08-31 DOI:10.1016/j.etap.2024.104548

Hailun Fang , Juan Li , Lei Zhang , Baichun Li , Jing Song , Xiaoting Lu , Qiao Niu , Linping Wang

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引用次数: 0

摘要

目的：评估lncRNA 51A在检测职业铝暴露工人认知能力下降方面的诊断效用：方法：921名来自铝制造厂的男性工人接受了认知评估、血浆铝水平测量和lncRNA 51A水平量化。通过构建接收者操作特征曲线（ROC）来评估lncRNA 51A的诊断潜力。利用贝叶斯网络模型预测研究人群认知能力下降的可能性：结果：在认知能力正常组和认知能力下降组之间，lncRNA 51A水平、血浆铝浓度和MMSE评分存在显著差异。lncRNA 51A 的表达与 MMSE 评分呈负相关。曲线下面积（AUC）为0.894，灵敏度为89.3%，特异度为73.9%。贝叶斯网络模型显示，根据lncRNA 51A的表达水平，认知能力下降的概率各不相同：结论：血浆lncRNA 51A是诊断铝暴露工人认知功能衰退的一种极佳生物标记物。

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LncRNA 51A: A promising diagnostic biomarker for assessing cognitive decline in occupationally exposed aluminum workers

Objective

To assess the diagnostic utility of lncRNA 51 A in detecting cognitive decline among aluminum-exposed workers occupationally.

Methods

921 male workers from an aluminum manufacturing facility underwent cognitive assessments, measurement of plasma aluminum levels and quantification of lncRNA 51 A levels. Receiver Operating Characteristic (ROC) curves were constructed to assess the diagnostic potential of lncRNA 51 A. Bayesian network model was utilized to predict the likelihood of cognitive decline among the study population.

Results

Significant differences in lncRNA 51 A levels, plasma aluminum concentration and MMSE scores were observed between cognitive normal and decline groups. The lncRNA 51 A expression was negatively correlated with MMSE scores. The area under the curve (AUC) was 0.894, with 89.3 % sensitivity and 73.9 % specificity. The Bayesian network model indicated varying probabilities of cognitive decline based on lncRNA 51 A expression levels.

Conclusion

Plasma lncRNA 51 A shows potential as an excellent biomarker for cognitive decline diagnosis in aluminum-exposed workers.

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.