拉曼-反射组合在量化肝脏脂肪变性和脂肪滴大小方面的潜力：来自蒙特卡罗模拟和模型研究的证据。

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2024-09-02 DOI:10.1002/jbio.202400156

Hao Guo, Vanessa S. Zions, Brent A. Law, Kevin C. Hewitt

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引用次数: 0

摘要

本研究探索了一种拉曼和反射光谱相结合的策略，用于量化肝脏脂肪含量和脂肪滴大小，这对评估供体肝脏至关重要。通过使用蒙特卡罗模拟和水包油模型的实验装置，我们的研究结果表明，拉曼散射可以单独区分不同的脂肪含量。同时，反射强度受脂肪含量和油滴大小的影响，而对油滴大小的敏感性更为明显。这项研究证明了拉曼和反射光谱法在评估肝脏脂肪变性和油滴大小方面的功效，可能有助于评估供体肝脏的移植情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Potential of Raman-Reflectance Combination in Quantifying Liver Steatosis and Fat Droplet Size: Evidence From Monte Carlo Simulations and Phantom Studies

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Potential of Raman-Reflectance Combination in Quantifying Liver Steatosis and Fat Droplet Size: Evidence From Monte Carlo Simulations and Phantom Studies

This study explores a combined strategy of Raman and reflectance spectroscopy for quantifying liver fat content and fat droplet size, crucial in assessing donor livers. By using Monte Carlo simulations and experimental setups with oil-in-water phantoms, our findings indicate that Raman scattering can solely differentiate between varying fat contents. At the same time, reflectance intensity is influenced by both fat content and oil droplet size, with a more pronounced sensitivity to fat droplet size. This study demonstrates the efficacy of combined Raman and reflectance spectroscopy in assessing liver steatosis and fat droplet size, potentially aiding in assessing donor livers for transplantation.

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.