利用光学相干弹性成像技术表征韧带生物力学特性

Journal of biophotonics Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI:10.1002/jbio.202400275
Yubao Zhang, Yue Wang, Xiao Han, Jiahui Luo, Chuanqi Lin, Qin Zhang, Xingdao He
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引用次数: 0

摘要

角膜缘的弹性对眼部健康至关重要,但目前对它的研究还很不够。本研究采用声辐射力光学相干弹性成像(ARF-OCE)来评估不同眼压下眼球边缘的生物力学特性。该方法通过一个异质模型进行了验证,随后应用于体外猪瓣膜样本。计算了瓣膜特定位置的弹性波速度,并获得了相应的杨氏模量值。通过将杨氏模量值与其在二维结构图像中的相应位置相关联,生成了空间弹性分布图。结果表明,ARF-OCE 增强了对角膜缘生物力学行为的理解,并具有诊断由眼部疾病引起的区域性变化的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of Limbus Biomechanical Properties Using Optical Coherence Elastography.

The elasticity of the limbus is crucial for ocular health, yet it remains inadequately explored. This study employs acoustic radiation force optical coherence elastography (ARF-OCE) to evaluate the biomechanical properties of the limbus under varying intraocular pressures. The method was validated using a heterogeneous phantom and subsequently applied to ex vivo porcine limbus samples. Elastic wave velocity at specific locations within the limbus was calculated, and the corresponding Young's modulus values were obtained. Spatial elasticity distribution maps were generated by correlating Young's modulus values with their respective locations in the two-dimensional structural images. The results indicate that ARF-OCE enhances the understanding of limbus biomechanical behavior and holds potential for diagnosing regional variations caused by ocular diseases.

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