女性性欲减退症:确保更好地理解、诊断和应对治疗的新可能性。

IF 3.3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Elisa Maseroli, Sarah Cipriani, Valeria Lanzi, Serena Anna Ravelli, Mattia Annunziato, Chiara Alfaroli, Donatella Lippi, Michela Cirillo, Giovanni Castellini, Annamaria Giraldi, Mario Maggi, Linda Vignozzi
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引用次数: 0

摘要

背景:性欲减退症(HSDD)是女性中经常出现的性相关问题;然而,目前仍缺乏根据性抑制和性兴奋因素来描述 HSDD 亚型的特定工具。目的:(1)找到性抑制量表(SIS)/性兴奋量表(SES)得分的临界值,以预测因性功能症状就诊的女性是否被诊断为HSDD;(2)根据新发现的临界值对样本进行分层,探索因女性性功能障碍就诊的女性的性抑制和性兴奋特征;(3)确定与这两种特征显著相关的生物心理社会因素:对 133 名因性功能症状就诊的女性进行了回顾性评估,收集了她们首次就诊时的临床、生化和性心理数据。对 55 名接受透皮睾酮治疗的女性进行了回顾性分析:结果:患者接受了身体检查和实验室检查,并完成了 SIS/SES、女性性功能指数、女性性苦恼量表-修订版、情绪化饮食量表和米德尔塞克斯医院问卷调查:结果发现:SIS1(≥32.5,表示有可能表现失败)和 SES(≤46.5)的特定临界值预测 HSDD 诊断的准确率分别为 66.4% (P = .002) 和 68.7% (P 临床翻译):更好地描述 HSDD 的特征将有助于根据主要的潜在病因进行个体化治疗:该研究的局限性包括样本量小和横断面回顾性设计,HSDD 的治疗选择仅限于透皮睾酮。优点是对可能影响性欲的抑制和兴奋成分的各个方面进行了全面、多因素的评估:经过验证的 SIS/SES 分值临界值可以深入分析被诊断为 HSDD 的女性的特征,从而确保更好地定制治疗方案,并预测对特定治疗方案产生反应的概率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypoactive sexual desire disorder in women: new possibilities to ensure better understanding, diagnosis, and response to treatment.

Background: Hypoactive Sexual Desire Disorder (HSDD) is a frequent sex-related problem in women; however, a specific tool to characterize HSDD subtypes based on sexual inhibitory and excitatory factors is still lacking.

Aim: (1) To find a cutoff value in Sexual Inhibition Scale (SIS)/Sexual Excitation Scale (SES) scores predicting a diagnosis of HSDD in women consulting for sexual symptoms, (2) to explore the sexual inhibitory and excitatory profiles in women referred to a clinic for female sexual dysfunction by stratifying the sample according to the newfound cutoffs, and (3) to identify biopsychosocial factors significantly associated with the 2 profiles.

Methods: An overall 133 women consulting for sexual symptoms were retrospectively evaluated for clinical, biochemical, and psychosexologic data collected at the first visit. A subgroup of 55 women treated with transdermal testosterone was retrospectively analyzed at baseline and the 6-month visit.

Outcomes: Patients underwent physical and laboratory examinations and completed the SIS/SES, Female Sexual Function Index, Female Sexual Distress Scale-Revised, Emotional Eating Scale, and Middlesex Hospital Questionnaire.

Results: Specific cutoffs for SIS1 (≥32.5; indicating threat of performance failure) and SES (≤46.5) predicted HSDD diagnosis with an accuracy of 66.4% (P = .002) and 68.7% (P < .0001), respectively. Patients with impaired SIS1 scores showed higher distress and psychopathologic symptoms, while those with impaired SES scores demonstrated lower desire and arousal and a negative association with some metabolic and hormonal parameters. SES score also showed a significant predictive value on testosterone treatment efficacy for HSDD.

Clinical translation: A better characterization of HSDD would enable individualized treatment based on the main underlying etiologies.

Strengths and limitations: Limitations of the study include the small sample size and cross-sectional retrospective design, with the choice of treatment for HSDD limited to transdermal testosterone. Strengths comprise the thorough and multifactorial evaluation of every aspect potentially affecting inhibitory and excitatory components of sexual desire.

Conclusion: Validated cutoffs of SIS/SES scores could allow deep characterization of women diagnosed with HSDD, thus ensuring better tailoring of therapy and prediction of the probability of response to specific treatments.

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来源期刊
Journal of Sexual Medicine
Journal of Sexual Medicine 医学-泌尿学与肾脏学
CiteScore
6.20
自引率
5.70%
发文量
826
审稿时长
2-4 weeks
期刊介绍: The Journal of Sexual Medicine publishes multidisciplinary basic science and clinical research to define and understand the scientific basis of male, female, and couples sexual function and dysfunction. As an official journal of the International Society for Sexual Medicine and the International Society for the Study of Women''s Sexual Health, it provides healthcare professionals in sexual medicine with essential educational content and promotes the exchange of scientific information generated from experimental and clinical research. The Journal of Sexual Medicine includes basic science and clinical research studies in the psychologic and biologic aspects of male, female, and couples sexual function and dysfunction, and highlights new observations and research, results with innovative treatments and all other topics relevant to clinical sexual medicine. The objective of The Journal of Sexual Medicine is to serve as an interdisciplinary forum to integrate the exchange among disciplines concerned with the whole field of human sexuality. The journal accomplishes this objective by publishing original articles, as well as other scientific and educational documents that support the mission of the International Society for Sexual Medicine.
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