蚕丝素在伤口愈合方面的治疗潜力。

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI:10.1111/wrr.13216
Monika Prakash, Chandraprabha Mathikere Naganna, Vivek Radhakrishnan, Prathik Somayaji, Leah Sabu
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引用次数: 0

摘要

慢性伤口的特点是促炎和抗炎信号失衡,导致永久性炎症和再上皮化延迟,从而阻碍伤口愈合。它们与细菌感染、组织缺氧、局部缺血、血管生成减少和 MMP-9 上调有关。据估计,全球成年人口中慢性伤口的发病率为 4000 万,每年以 6.6% 的惊人速度增长,使其成为一个日益严重的临床问题。丝胶是从蚕茧中提取的一种天然亲水性蛋白质。由于它具有生物相容性、生物可降解性、非免疫原性和抗氧化性,再加上对目标生物大分子具有极佳的亲和力,因此在伤口愈合方面具有巨大的应用潜力。蚕丝业每年丢弃 5 万吨丝胶,因此丝胶是一种现成的材料。丝胶具有细胞保护和有丝分裂作用,可增加细胞结合点,促进成纤维细胞和角质细胞的增殖。此外,它还能刺激巨噬细胞释放更多治疗细胞因子,从而改善血管生成。本综述重点介绍丝胶的生物特性,这些特性有助于增强伤口愈合过程,以及丝胶与参与伤口愈合的重要生物靶点的相互作用机制。重点介绍以丝胶为基础的各种伤口敷料产品,以及利用纳米技术设计丝胶纳米颗粒以帮助慢性伤口管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic potential of silkworm sericin in wound healing applications.

Chronic wounds are characterised by an imbalance between pro and anti-inflammatory signals, which result in permanent inflammation and delayed re-epithelialization, consequently hindering wound healing. They are associated with bacterial infections, tissue hypoxia, local ischemia, reduced vascularization and MMP-9 upregulation. The global prevalence of chronic wounds has been estimated at 40 million in the adult population, with an alarming annual growth rate of 6.6%, making it an increasingly significant clinical problem. Sericin is a natural hydrophilic protein obtained from the silkworm cocoon. Due to its biocompatibility, biodegradability, non-immunogenicity and oxidation resistance, coupled with its excellent affinity for target biomolecules, it holds great potential in wound healing applications. The silk industry discards 50,000 tonnes of sericin annually, making it a readily available material. Sericin increases cell union sites and promotes cell proliferation in fibroblasts and keratinocytes, thanks to its cytoprotective and mitogenic effects. Additionally, it stimulates macrophages to release more therapeutic cytokines, thus improving vascularization. This review focuses on the biological properties of sericin that contribute towards enhanced wound healing process and its mechanism of interaction with important biological targets involved in wound healing. Emphasis is placed on diverse wound dressing products that are sericin based and the utilisation of nanotechnology to design sericin nanoparticles that aid in chronic wound management.

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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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