橄榄油中的多酚羟基酪醇能改善糖尿病小鼠皮肤伤口的愈合。

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI:10.1111/wrr.13217
Matheus Silva Duarte, Victor Müller Fuhro, Jeane de Souza Nogueira, Bruna Romana-Souza
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引用次数: 0

摘要

氧化剂生成失衡和慢性炎症是导致糖尿病对皮肤伤口愈合产生不利影响的主要机制。因此,服用抗氧化剂可以改善糖尿病伤口愈合。本研究旨在了解特级初榨橄榄油(EVOO)或羟基酪醇(HT)对糖尿病条件下皮肤伤口愈合的影响。用 HT 局部治疗链脲佐菌素诱导的糖尿病小鼠的皮肤伤口。一些糖尿病动物的饮食中含有丰富的环氧乙烷。7 天后收获伤口。在体外试验中,成纤维细胞和巨噬细胞接受高浓度葡萄糖和 HT 处理。EVOO或HT促进了糖尿病小鼠伤口的闭合和胶原蛋白的沉积。EVOO 或 HT 可减少糖尿病小鼠伤口中浸润的中性粒细胞数量、肿瘤坏死因子-α、脂质过氧化和核因子红细胞 2 相关因子 2。EVOO 或 HT 还能增加糖尿病小鼠伤口中具有抗炎表型的巨噬细胞数量和白细胞介素-10。在体外实验中,HT 可促进成纤维细胞迁移、胶原凝胶收缩,并使巨噬细胞在高糖条件下转为抗炎表型。总之,在饮食中补充乙烯酪脂或局部应用 HT 可促进糖尿病条件下的皮肤伤口愈合,可作为治疗这些病变的一种可能的治疗工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polyphenol hydroxytyrosol present olive oil improves skin wound healing of diabetic mice.

The imbalance in oxidant production and chronic inflammation are the main mechanisms that lead to the detrimental effects of diabetes on skin wound healing. Thus, administration of antioxidants could improve diabetic wound healing. This study aimed to understand the effects of extra virgin olive oil (EVOO) or hydroxytyrosol (HT) in skin wound healing under diabetic conditions. Skin wounds in streptozotocin-induced diabetic mice were topically treated with HT. Some diabetic animals were fed with a diet rich in EVOO. Wounds were harvested 7 days later. In in vitro assays, fibroblasts and macrophages were treated with high levels of glucose and HT. The EVOO or HT promoted wound closure and collagen deposition in diabetic mouse wounds. The EVOO or HT reduced the number of infiltrated neutrophils, tumour necrosis factor-α, lipid peroxidation, and nuclear factor erythroid 2-related factor 2 in diabetic mouse wounds. The EVOO or HT also increased the number of macrophages with anti-inflammatory phenotype and interleukin-10 in diabetic mouse wounds. In the in vitro assays, HT promoted the fibroblast migration, collagen gel contraction, and switched macrophages to an anti-inflammatory phenotype under high glucose conditions. In conclusion, the diet supplementation with EVOO or topical application of HT promotes skin wound healing under diabetic conditions and can be a possible therapeutic tool for the treatment of those lesions.

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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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