小胶质细胞与 glymphatic 系统的昼夜节律同步,并调节 glymphatic 系统的功能。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
IUBMB Life Pub Date : 2024-09-02 DOI:10.1002/iub.2903
Ting Yang, Yan Tang, Xinghua Liu, Song Gong, Ensheng Yao
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引用次数: 0

摘要

作为中枢神经系统的免疫细胞,小胶质细胞具有在形态和功能上适应环境的能力。淋巴系统是大脑中主要的废物清除系统,具有昼夜节律。然而,小胶质细胞对甘油系统功能的影响仍然未知。在这项研究中,我们探讨了小胶质细胞与甘液系统之间错综复杂的关系。通过研究昼夜模式,我们发现了甘液活动和小胶质细胞形态的同步行为,这种行为在睡眠期间达到高峰,并在分支复杂性方面表现出明显的变化。使用 PLX5622 或在 P2Y12 基因敲除小鼠中消耗小神经胶质细胞可增强 glymphatic 功能。对小胶质细胞的化学遗传操作表明,激活 HM3D 可改善肾脏功能,而抑制 HM4D 则会意外地增加小胶质细胞的复杂性。这些发现凸显了小胶质细胞对 glymphatic 系统的动态影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function.

Microglia, as immune cells in the central nervous system, possess the ability to adapt morphologically and functionally to their environment. Glymphatic system, the principal waste clearance system in the brain, exhibits circadian rhythms. However, the impact of microglia on the glymphatic system function remains unknown. In this study, we explored the intricate relationship between microglia and the glymphatic system. Examining diurnal patterns, we identified synchronized behaviors in glymphatic activity and microglial morphology, peaking during sleep and exhibiting distinct changes in branching complexity. Depleting microglia using PLX5622 or in P2Y12 knockout mice enhanced glymphatic function. Chemogenetic manipulation of microglia demonstrated that activating HM3D improved glymphatic function, while inhibiting HM4D unexpectedly increased microglial complexity. These findings highlight the dynamic influence of microglia on the glymphatic system.

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来源期刊
IUBMB Life
IUBMB Life 生物-生化与分子生物学
CiteScore
10.60
自引率
0.00%
发文量
109
审稿时长
4-8 weeks
期刊介绍: IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
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