白藜芦醇通过保护 Nrf2 通路和 GSH 合成缓解 T-2 毒素诱导的肝损伤

IF 4.4 3区 医学 Q2 ENVIRONMENTAL SCIENCES
Hong Jin, Jun He, Min Wu, Xiaohan Wang, Li Jia, Li Zhang, Jiabin Guo
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引用次数: 0

摘要

T-2 毒素是一种单端孢霉烯霉菌毒素,被认为是一种不可避免的污染物,具有强烈的肝毒性。然而,如何缓解 T-2 毒素引发的肝脏毒性一直是一个严峻的挑战。白藜芦醇(Res)是从多种植物中分离出来的一种多酚天然产物,但它对 T-2 毒素肝毒性的保护作用及其详细机制仍不清楚。本研究以小鼠为研究对象,评估了白藜芦醇对肝毒性的抑制作用,并进一步揭示了其作用机制。在功能上,Res 可抑制 T-2 毒素诱导的肝损伤、氧化损伤和线粒体功能障碍。机制上,Res 调节了 Nrf2 介导的抗氧化途径和谷胱甘肽合成抑制。总之,我们的研究结果首次毫无疑问地表明,Res能通过调节Nrf2通路改善T-2毒素诱发的小鼠肝损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resveratrol Alleviated T-2 Toxin-Induced Liver Injury via Preservation of Nrf2 Pathway and GSH Synthesis

T-2 toxin is a trichothecene mycotoxin and is considered as an extremely inevitable pollutant with potent hepatotoxicity. However, the approach to alleviation of T-2 toxin-triggered hepatotoxicity has been recognized as a serious challenge. Resveratrol (Res) is a polyphenol natural product isolated from various plant species, but its protective effect against T-2 toxin hepatotoxicity and detailed mechanism remains obscure. In the present study, the effect of Res against the hepatotoxicity was evaluated, and the underlying mechanisms were further revealed in mice. Functionally, Res inhibited liver injury, oxidative damage, and mitochondrial dysfunction induced by T-2 toxin. Mechanistically, Res modulated Nrf2-mediated antioxidant pathway and glutathione synthesis inhibition. Collectively, our findings first showed beyond doubt that Res ameliorated T-2 toxin-triggered liver injury by regulating Nrf2 pathways in mice.

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来源期刊
Environmental Toxicology
Environmental Toxicology 环境科学-毒理学
CiteScore
7.10
自引率
8.90%
发文量
261
审稿时长
4.5 months
期刊介绍: The journal publishes in the areas of toxicity and toxicology of environmental pollutants in air, dust, sediment, soil and water, and natural toxins in the environment.Of particular interest are: Toxic or biologically disruptive impacts of anthropogenic chemicals such as pharmaceuticals, industrial organics, agricultural chemicals, and by-products such as chlorinated compounds from water disinfection and waste incineration; Natural toxins and their impacts; Biotransformation and metabolism of toxigenic compounds, food chains for toxin accumulation or biodegradation; Assays of toxicity, endocrine disruption, mutagenicity, carcinogenicity, ecosystem impact and health hazard; Environmental and public health risk assessment, environmental guidelines, environmental policy for toxicants.
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