天然活性成分和化合物对角质细胞和成纤维细胞缓解皮肤光老化的调节机制。

IF 1.9 4区 医学 Q3 DERMATOLOGY
Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S478666
Xinru Hu, Meng Chen, Jahanzeb Nawaz, Xi Duan
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引用次数: 0

摘要

背景:皮肤光老化的内在机理仍然难以捉摸,因为导致这一现象的细胞和分子变化错综复杂,至今尚未阐明。在光老化过程中,角质形成细胞和成纤维细胞对维持皮肤结构和弹性至关重要。但这些细胞在光老化过程中会受到光诱导损伤,导致皮肤形态发生变化。近来,天然活性成分在治疗和预防光老化方面的功能引起了越来越多的关注,而研究的重点往往是角质细胞和成纤维细胞:我们通过以下关键词在 Web of Science、PubMed 和 ScienceDirect 数据库中检索了 2007 年至 2024 年 1 月发表的研究:天然植物、天然植物产品或植物化学物质、中医或中草药、植物提取物、日光性皮肤老化、皮肤光老化和皮肤皱纹。本综述根据《系统综述和元分析首选报告项目》指南进行:本综述共纳入了 87 项研究(图 1)。在角质细胞中,天然化合物可能主要调节信号通路,如 NF-κB、MAPK、PI3K/AKT 和 Nrf2/ARE 通路,减少炎症和细胞损伤,从而减缓皮肤光老化。此外,在成纤维细胞中,天然活性成分主要促进 TGF-β 通路,抑制 MMPs 活性,促进胶原蛋白合成,同时可能调节 mTOR 通路,从而保护真皮胶原蛋白网络,减少皱纹形成。一些试验表明,调节角质细胞和成纤维细胞反应的天然化合物具有显著而安全的治疗效果:结论:在防晒配方中添加天然产品成分的需求正在上升。天然化合物通过靶向角质细胞和成纤维细胞中的细胞通路,显示出良好的抗光老化效果,提供了潜在的治疗策略。然而,还需要进行全面的临床研究,以验证它们在缓解光老化方面的有效性和安全性,这些研究应使用先进的药理学方法来揭示天然化合物复杂的抗光老化机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulatory Mechanisms of Natural Active Ingredients and Compounds on Keratinocytes and Fibroblasts in Mitigating Skin Photoaging.

Background: The mechanism underlying skin photoaging remains elusive because of the intricate cellular and molecular changes that contribute to this phenomenon, which have yet to be elucidated. In photoaging, the roles of keratinocytes and fibroblasts are vital for maintaining skin structure and elasticity. But these cells can get photo-induced damage during photoaging, causing skin morphological changes. Recently, the function of natural active ingredients in treating and preventing photoaging has drawn more attention, with researches often focusing on keratinocytes and fibroblasts.

Methods: We searched for studies published from 2007 to January 2024 in the Web of Science, PubMed, and ScienceDirect databases through the following keywords: natural plant, natural plant products or phytochemicals, traditional Chinese Medicine or Chinese herbal, plant extracts, solar skin aging, skin photoaging, and skin wrinkling. This review conducted the accordance of Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.

Results: In total, 87 researches were included in this review (Figure 1). In keratinocytes, natural compounds may primarily regulate signal pathways such as the NF-κB, MAPK, PI3K/AKT, and Nrf2/ARE pathways, reducing inflammation and cellular damage, thus slowing skin photoaging. Additionally, in fibroblasts, natural active ingredients primarily promote the TGF-β pathway, inhibit MMPs activity, and enhance collagen synthesis while potentially modulating the mTOR pathway, thereby protecting the dermal collagen network and reducing wrinkle formation. Several trials showed that natural compounds that regulate keratinocytes and fibroblasts responses have significant and safe therapeutic effects.

Conclusion: The demand for natural product-based ingredients in sunscreen formulations is rising. Natural compounds show promising anti-photoaging effects by targeting cellular pathways in keratinocytes and fibroblasts, providing potential therapeutic strategies. However, comprehensive clinical studies are needed to verify their efficacy and safety in mitigating photoaging, which should use advanced pharmacological methods to uncover the complex anti-photoaging mechanisms of natural compounds.

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来源期刊
CiteScore
2.80
自引率
4.30%
发文量
353
审稿时长
16 weeks
期刊介绍: Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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