L. Tourvieilhe , F. Salvo , V. Bréant , B. Kassai , A. Portefaix
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引用次数: 0
摘要
干扰内分泌的化学品 (EDC) 可能会影响儿童的健康，而药物则可能是一个接触源。目的：评估作为 EDC 的儿科药物和精油中的物质对儿童的潜在影响。这是一项采用 PECOT 方法对包括 Medline 在内的五个数据库进行的系统性综述。综述的重点是有关儿童接触药物（活性成分或相关辅料）并出现内分泌功能障碍临床症状的出版物。在已确定的 946 项研究中，有 28 项研究被纳入其中。研究结果显示，对羟基苯甲酸酯、薰衣草精油和抗癫痫药是最常见的药物产品。报告的结果与青春期、甲状腺疾病、肥胖和生长有关。证据表明存在潜在风险，但现有数据的总体质量有限。本系统综述揭示了儿科药物暴露与 EDC 相关的有力证据缺乏，主要依赖于病例报告。它提醒人们注意潜在的利益冲突。
Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals
Endocrine disrupting chemicals (EDCs) may impact children's health, with medicines as a possible exposure source. Objective: to assess the potential impact of substances in paediatric medications and essential oils on children as EDC. It is a systematic review of five databases including Medline following the PECOT approach. The review focused on publications about children exposed to medication (active ingredients or excipients of interest) and having developed clinical signs of endocrine dysfunction. Out of 946 studies identified, 28 studies were included. They revealed that parabens, lavender essential oils and anti-epileptics are the most identified pharmaceutical products. The reported outcomes relate to puberty, thyroid disorders, obesity and growth. The evidence indicates potential risks, but the overall quality of available data is limited. This systematic review exposes a lack of robust evidence linking paediatric medication exposure to EDC, predominantly relying on case reports. It cautions about potential conflicts of interest.
期刊介绍：
Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man.
Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals.
In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.
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