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引用次数: 0
摘要
细菌性脑脓肿(BA)是一种局灶性脑部感染,其长期影响尚不清楚。这项前瞻性研究评估了脑脓肿术后 8 周和 1 年的疲劳频率和抑郁症状,并研究了疲劳、抑郁症状和认知状况之间的关系。研究人员对 20 名 BA 患者(17-73 岁;45% 为女性)进行了疲劳、抑郁、记忆和执行功能评估。在各种疲劳问卷中,8周时的疲劳率为40%-65%,1年时为25%-33%。患者健康问卷显示,仅在 8 周随访时有 10% 的患者出现抑郁症状。相关合并症和职业结果与疲劳或抑郁症状无关。在两个时间点之间,平均疲劳评分有了明显改善。更严重的疲劳与工作记忆、抑制、自我监控和情绪控制方面的主观问题以及更差的客观言语记忆表现有关。抑郁症状与两项疲劳测量中的一项相关。我们的结论是,疲劳在 BA 后的第一年很常见,疲劳程度越高,认知问题越多。临床抑郁症状很少见。这些发现强调了疲劳是脑损伤后的一个重要后果,并强调有必要采取有针对性的康复干预措施。
Fatigue and depression at 8 weeks and 1 year after bacterial brain abscess and their relationship with cognitive status.
A bacterial brain abscess (BA) is a focal brain infection with largely unknown long-term implications. This prospective study assessed the frequency of fatigue and symptoms of depression at 8 weeks and 1 year after BA and examined the relationship between fatigue, depressive symptoms, and cognitive status. Twenty BA-patients (age 17-73; 45% female) were assessed for fatigue, depression, memory, and executive functions. Fatigue rates were 40-65% at 8 weeks and 25-33% at 1 year on various fatigue questionnaires. Patient Health Questionnaire indicated symptoms of depression in 10% at the 8-week follow-up only. Relevant comorbidities and vocational outcomes were not associated with fatigue or symptoms of depression. Mean fatigue scores improved significantly between the two-time points. Greater fatigue was related to subjective problems with working memory, inhibition, self-monitoring, and emotional control and worse objective verbal memory performance. Symptoms of depression were associated with one out of two fatigue measures. We conclude that fatigue is common in the first year after BA, and higher levels of fatigue are related to more cognitive problems. Symptoms of clinical depression were rare. These findings underscore fatigue as an important consequence of BA and emphasize the necessity for targeted rehabilitation interventions.
期刊介绍:
Neuropsychological Rehabilitation publishes human experimental and clinical research related to rehabilitation, recovery of function, and brain plasticity. The journal is aimed at clinicians who wish to inform their practice in the light of the latest scientific research; at researchers in neurorehabilitation; and finally at researchers in cognitive neuroscience and related fields interested in the mechanisms of recovery and rehabilitation. Papers on neuropsychological assessment will be considered, and special topic reviews (2500-5000 words) addressing specific key questions in rehabilitation, recovery and brain plasticity will also be welcomed. The latter will enter a fast-track refereeing process.