DNA损伤修复蛋白OGG1与泛素化途径蛋白STUB1在小儿神经母细胞瘤中表达的相关性

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-09-01 DOI:10.1080/15513815.2024.2393351

Bo Shao, Yi-Zhen Wang, Yuan Fang

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引用次数: 0

摘要

背景：神经母细胞瘤是一种儿科恶性肿瘤，受遗传因素的影响很大。先前的研究表明，OGG1 rs1052133 G > C 多态性与神经母细胞瘤风险的降低有关：我们分析了 57 例神经母细胞瘤样本和 21 例肾上腺样本，使用免疫组化方法测量 OGG1 和 STUB1 的表达水平。结果：OGG1的表达量明显高于STUB1：结果：在神经母细胞瘤中，OGG1的表达明显较高，STUB1的表达明显较低。OGG1水平与患者年龄、肿瘤位置、组织学分级、岛田分类、INSS分期和风险类别明显相关。OGG1和STUB1的表达呈负相关。较高的OGG1表达与较低的PFS和OS有关。较低的 STUB1 表达与较差的 PFS 相关。此外，OGG1的表达和风险类别也是预后的独立预测因素：结论：OGG1可能是NB中的致癌基因，其活性可能受STUB1通过泛素化途径调节。

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Correlation Between the Expression of DNA Damage Repair Protein OGG1 and Ubiquitination Pathway Protein STUB1 in Pediatric Neuroblastoma.

Background: Neuroblastoma, a pediatric malignancy, is significantly influenced by genetic factors. Prior research indicates that the OGG1 rs1052133 G > C polymorphism correlates with a decreased risk of neuroblastoma.

Methods: We analyzed 57 neuroblastoma and 21 adrenal samples, using immunohistochemistry to measure OGG1 and STUB1 expression levels. We conducted a survival analysis to explore relationship between the expressions and neuroblastoma prognosis.

Results: Notably higher OGG1 expression and significantly lower STUB1 expression in neuroblastoma. OGG1 levels were significantly correlated with patient age, tumor location, histological grade, Shimada classification, INSS stage, and risk category. A negative association was observed between OGG1 and STUB1 expressions. Higher OGG1 expression was linked to reduced PFS and OS. Lower STUB1 expression was associated with unfavorable PFS. Additionally, OGG1 expression and risk category emerged as independent predictors of prognosis.

Conclusion: OGG1 potentially functions as an oncogene in NB, with its activity possibly modulated by STUB1 through the ubiquitination pathway.

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.