健康主动脉瓣及其周围血流动力学的流体-结构相互作用分析。

IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Zhongjie Yin, Chlöe Armour, Harkamaljot Kandail, Declan P. O'Regan, Toufan Bahrami, Saeed Mirsadraee, Selene Pirola, Xiao Yun Xu
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引用次数: 0

摘要

主动脉瓣(AV)的开闭动力学对主动脉根部的血流动力学有很大影响,两者在维持瓣膜正常生理功能方面起着关键作用。本研究的目的是建立一个特定受试者的流体-结构相互作用(FSI)工作流程,该流程能够在生理真实条件下模拟三尖瓣健康瓣膜的运动和周围血流动力学。根据从健康志愿者身上获取的磁共振(MR)图像重建了特定受试者的主动脉根部,同时使用与特定受试者主动脉根部几何形状相匹配的参数模型构建了瓣叶。瓣叶的材料行为使用各向同性超弹性奥格登模型进行描述,特定受试者的边界条件则来自四维流磁共振成像(4D-MRI)。强耦合 FSI 模拟是使用 FlowVision 中实施的基于有限体积的边界符合方法进行的。我们的 FSI 模型能够模拟整个心动周期中房室的开放和关闭。模拟结果与 4D-MRI 的比较显示,两者在关键血流动力学参数上具有良好的一致性,每搏量相差 7.5%,最大射流速度相差不到 1%。对瓣叶壁剪应力(WSS)的详细分析显示,心室一侧的 WSS 远高于主动脉一侧,而且三个瓣叶之间的空间模式不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fluid–structure interaction analysis of a healthy aortic valve and its surrounding haemodynamics

Fluid–structure interaction analysis of a healthy aortic valve and its surrounding haemodynamics

The opening and closing dynamics of the aortic valve (AV) has a strong influence on haemodynamics in the aortic root, and both play a pivotal role in maintaining normal physiological functions of the valve. The aim of this study was to establish a subject-specific fluid–structure interaction (FSI) workflow capable of simulating the motion of a tricuspid healthy valve and the surrounding haemodynamics under physiologically realistic conditions. A subject-specific aortic root was reconstructed from magnetic resonance (MR) images acquired from a healthy volunteer, whilst the valve leaflets were built using a parametric model fitted to the subject-specific aortic root geometry. The material behaviour of the leaflets was described using the isotropic hyperelastic Ogden model, and subject-specific boundary conditions were derived from 4D-flow MR imaging (4D-MRI). Strongly coupled FSI simulations were performed using a finite volume-based boundary conforming method implemented in FlowVision. Our FSI model was able to simulate the opening and closing of the AV throughout the entire cardiac cycle. Comparisons of simulation results with 4D-MRI showed a good agreement in key haemodynamic parameters, with stroke volume differing by 7.5% and the maximum jet velocity differing by less than 1%. Detailed analysis of wall shear stress (WSS) on the leaflets revealed much higher WSS on the ventricular side than the aortic side and different spatial patterns amongst the three leaflets.

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来源期刊
International Journal for Numerical Methods in Biomedical Engineering
International Journal for Numerical Methods in Biomedical Engineering ENGINEERING, BIOMEDICAL-MATHEMATICAL & COMPUTATIONAL BIOLOGY
CiteScore
4.50
自引率
9.50%
发文量
103
审稿时长
3 months
期刊介绍: All differential equation based models for biomedical applications and their novel solutions (using either established numerical methods such as finite difference, finite element and finite volume methods or new numerical methods) are within the scope of this journal. Manuscripts with experimental and analytical themes are also welcome if a component of the paper deals with numerical methods. Special cases that may not involve differential equations such as image processing, meshing and artificial intelligence are within the scope. Any research that is broadly linked to the wellbeing of the human body, either directly or indirectly, is also within the scope of this journal.
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