在 COVID-19 大流行期间,英格兰与革兰氏阴性血流感染相关的 30 天全因死亡率增加。

IF 14.3 1区 医学 Q1 INFECTIOUS DISEASES
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引用次数: 0

摘要

背景我们的目的是评估 COVID-19 大流行对住院革兰氏阴性血流感染(GNBSI)患者死亡率的影响:方法:一项回顾性队列研究,包括向英国卫生与健康协会第二代监测系统报告的英国大肠埃希菌、克雷伯氏菌和铜绿假单胞菌病例(2015年1月至2021年12月)。结果为 30 天全因死亡率。建立了多变量逻辑回归模型,并报告了调整后的比值比(ORs)和 95% 的置信区间:结果:大肠杆菌、克雷伯氏菌和铜绿假单胞菌感染总数分别为 206,030 例、53,819 例和 21,129 例。与大流行前相比,在大流行期间(2020 年 3 月起),在发病 28 天内未感染 COVID-19 的大肠杆菌、克雷伯氏菌属和铜绿假单胞菌感染者的死亡几率为 1.13(1.08-1.18)、1.15(1.07-1.25)和 1.09(0.97-1.22),而伴有 COVID-19 感染的 GNBSI 的几率分别为 2.45(2.26-2.66)、2.96(2.62-3.34)和 3.15(2.61-3.80)。与白人患者相比,感染 COVID-19 的亚裔患者在大流行期间死亡的几率更高(大肠杆菌:OR 1.28(0.95)):大肠杆菌:OR 1.28 (0.95-1.71);克雷伯氏菌:OR 1.59 (1.20-2.11);铜绿假单胞菌:OR 2.02 (1.23-3.31)):结论:大流行期间,GNBSI 患者的死亡风险增加,伴有 COVID-19 感染的患者死亡风险更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increased 30-day all-cause mortality associated with Gram-negative bloodstream infections in England during the COVID-19 pandemic

Background

Our aim was to assess the impact of COVID-19 pandemic on mortality in patients hospitalised with Gram-negative bloodstream infections (GNBSIs).

Methods

A retrospective cohort study including cases of Escherichia coli, Klebsiella species and Pseudomonas aeruginosa in England (January 2015–December 2021) reported to UKHSA’s Second Generation Surveillance System. The outcome was 30-day all-cause mortality. Multivariable logistic regression models were built, and adjusted Odds Ratios (ORs) with 95% confidence intervals were reported.

Results

Total E. coli, Klebsiella spp. and P. aeruginosa infections were 206,030, 53,819 and 21,129, respectively. Compared to the pre-pandemic period, odds of death during the pandemic (March 2020 onwards) in E. coli, Klebsiella spp. and P. aeruginosa infections with no COVID-19 infection within 28-days of onset were 1.13 (1.08–1.18), 1.15 (1.07–1.25) and 1.09 (0.97–1.22), while odds in GNBSIs with an associated COVID-19 infection were 2.45 (2.26–2.66), 2.96 (2.62–3.34) and 3.15 (2.61–3.80), respectively. Asian patients with an associated COVID-19 infection were more likely to die during the pandemic compared to White patients (E. coli: OR 1.28 (0.95–1.71); Klebsiella spp. OR 1.59 (1.20–2.11); P. aeruginosa: OR 2.02 (1.23–3.31)).

Conclusions

Patients suffering from a GNBSI had increased risk of death during the pandemic, with the risk higher in patients with an associated COVID-19 infection.

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来源期刊
Journal of Infection
Journal of Infection 医学-传染病学
CiteScore
45.90
自引率
3.20%
发文量
475
审稿时长
16 days
期刊介绍: The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.
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