{"title":"在 COVID-19 大流行期间,英格兰与革兰氏阴性血流感染相关的 30 天全因死亡率增加。","authors":"","doi":"10.1016/j.jinf.2024.106256","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Our aim was to assess the impact of COVID-19 pandemic on mortality in patients hospitalised with Gram-negative bloodstream infections (GNBSIs).</p></div><div><h3>Methods</h3><p>A retrospective cohort study including cases of <em>Escherichia coli</em>, <em>Klebsiella</em> species and <em>Pseudomonas aeruginosa</em> in England (January 2015–December 2021) reported to UKHSA’s Second Generation Surveillance System. The outcome was 30-day all-cause mortality. Multivariable logistic regression models were built, and adjusted Odds Ratios (ORs) with 95% confidence intervals were reported.</p></div><div><h3>Results</h3><p>Total <em>E. coli</em>, <em>Klebsiella</em> spp. and <em>P. aeruginosa</em> infections were 206,030, 53,819 and 21,129, respectively. Compared to the pre-pandemic period, odds of death during the pandemic (March 2020 onwards) in <em>E. coli</em>, <em>Klebsiella</em> spp. and <em>P. aeruginosa</em> infections with no COVID-19 infection within 28-days of onset were 1.13 (1.08–1.18), 1.15 (1.07–1.25) and 1.09 (0.97–1.22), while odds in GNBSIs with an associated COVID-19 infection were 2.45 (2.26–2.66), 2.96 (2.62–3.34) and 3.15 (2.61–3.80), respectively. Asian patients with an associated COVID-19 infection were more likely to die during the pandemic compared to White patients (<em>E. coli</em>: OR 1.28 (0.95–1.71); <em>Klebsiella</em> spp. OR 1.59 (1.20–2.11); <em>P. aeruginosa</em>: OR 2.02 (1.23–3.31)).</p></div><div><h3>Conclusions</h3><p>Patients suffering from a GNBSI had increased risk of death during the pandemic, with the risk higher in patients with an associated COVID-19 infection.</p></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":null,"pages":null},"PeriodicalIF":14.3000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163445324001907/pdfft?md5=bd503fcccf76cb926880cc1c7e0875de&pid=1-s2.0-S0163445324001907-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Increased 30-day all-cause mortality associated with Gram-negative bloodstream infections in England during the COVID-19 pandemic\",\"authors\":\"\",\"doi\":\"10.1016/j.jinf.2024.106256\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Our aim was to assess the impact of COVID-19 pandemic on mortality in patients hospitalised with Gram-negative bloodstream infections (GNBSIs).</p></div><div><h3>Methods</h3><p>A retrospective cohort study including cases of <em>Escherichia coli</em>, <em>Klebsiella</em> species and <em>Pseudomonas aeruginosa</em> in England (January 2015–December 2021) reported to UKHSA’s Second Generation Surveillance System. The outcome was 30-day all-cause mortality. Multivariable logistic regression models were built, and adjusted Odds Ratios (ORs) with 95% confidence intervals were reported.</p></div><div><h3>Results</h3><p>Total <em>E. coli</em>, <em>Klebsiella</em> spp. and <em>P. aeruginosa</em> infections were 206,030, 53,819 and 21,129, respectively. Compared to the pre-pandemic period, odds of death during the pandemic (March 2020 onwards) in <em>E. coli</em>, <em>Klebsiella</em> spp. and <em>P. aeruginosa</em> infections with no COVID-19 infection within 28-days of onset were 1.13 (1.08–1.18), 1.15 (1.07–1.25) and 1.09 (0.97–1.22), while odds in GNBSIs with an associated COVID-19 infection were 2.45 (2.26–2.66), 2.96 (2.62–3.34) and 3.15 (2.61–3.80), respectively. Asian patients with an associated COVID-19 infection were more likely to die during the pandemic compared to White patients (<em>E. coli</em>: OR 1.28 (0.95–1.71); <em>Klebsiella</em> spp. OR 1.59 (1.20–2.11); <em>P. aeruginosa</em>: OR 2.02 (1.23–3.31)).</p></div><div><h3>Conclusions</h3><p>Patients suffering from a GNBSI had increased risk of death during the pandemic, with the risk higher in patients with an associated COVID-19 infection.</p></div>\",\"PeriodicalId\":50180,\"journal\":{\"name\":\"Journal of Infection\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":14.3000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0163445324001907/pdfft?md5=bd503fcccf76cb926880cc1c7e0875de&pid=1-s2.0-S0163445324001907-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0163445324001907\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0163445324001907","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Increased 30-day all-cause mortality associated with Gram-negative bloodstream infections in England during the COVID-19 pandemic
Background
Our aim was to assess the impact of COVID-19 pandemic on mortality in patients hospitalised with Gram-negative bloodstream infections (GNBSIs).
Methods
A retrospective cohort study including cases of Escherichia coli, Klebsiella species and Pseudomonas aeruginosa in England (January 2015–December 2021) reported to UKHSA’s Second Generation Surveillance System. The outcome was 30-day all-cause mortality. Multivariable logistic regression models were built, and adjusted Odds Ratios (ORs) with 95% confidence intervals were reported.
Results
Total E. coli, Klebsiella spp. and P. aeruginosa infections were 206,030, 53,819 and 21,129, respectively. Compared to the pre-pandemic period, odds of death during the pandemic (March 2020 onwards) in E. coli, Klebsiella spp. and P. aeruginosa infections with no COVID-19 infection within 28-days of onset were 1.13 (1.08–1.18), 1.15 (1.07–1.25) and 1.09 (0.97–1.22), while odds in GNBSIs with an associated COVID-19 infection were 2.45 (2.26–2.66), 2.96 (2.62–3.34) and 3.15 (2.61–3.80), respectively. Asian patients with an associated COVID-19 infection were more likely to die during the pandemic compared to White patients (E. coli: OR 1.28 (0.95–1.71); Klebsiella spp. OR 1.59 (1.20–2.11); P. aeruginosa: OR 2.02 (1.23–3.31)).
Conclusions
Patients suffering from a GNBSI had increased risk of death during the pandemic, with the risk higher in patients with an associated COVID-19 infection.
期刊介绍:
The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection.
Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.