对类似甲基转移酶 1 在人类肿瘤中致癌作用的泛癌分析

IF 0.9 3区医学 Q4 NEUROSCIENCES

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI:10.4103/neurol-india.ni_1354_21

Ping Zheng, Shunmin Yang, Dabin Ren, Xiaoxue Zhang, Qingke Bai

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引用次数: 0

摘要

背景和目的：尽管新出现的基于细胞或动物的证据支持甲基转移酶样1（METTL1）与癌症之间的关系，但目前尚无泛癌症分析：因此，我们首先根据癌症基因组图谱和基因表达总库的数据集，探讨了METTL1在33种肿瘤中的潜在致癌作用：METTL1在大多数癌症中高表达，METTL1的表达与肿瘤患者的预后之间存在明显的关联。在大多数肿瘤中，METTL1水平与树突状细胞和B细胞浸润水平相关。此外，METTL1的功能机制还涉及RNA加工和RNA代谢相关功能：我们的泛癌症研究对METTL1在不同肿瘤中的致癌作用有了相对全面的了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Pan-Cancer Analysis of the Oncogenic Role of Methyltransferase-Like 1 in Human Tumors.

Background and object: Although emerging cell- or animal-based evidence supports the relationship between methyltransferase-like 1 (METTL1) and cancers, no pan-cancer analysis is available.

Methods: We thus first explored the potential oncogenic roles of METTL1 across 33 tumors based on the datasets of The Cancer Genome Atlas and Gene Expression Omnibus.

Results: METTL1 is highly expressed in most cancers, and distinct associations exist between METTL1 expression and prognosis of tumor patients. METTL1 level is related with the dendritic and B-cell infiltration levels in most tumors. Moreover, RNA processing- and RNA metabolism-associated functions were involved in the functional mechanisms of METTL1.

Conclusion: Our pan-cancer study offers a relatively comprehensive understanding of the oncogenic roles of METTL1 across different tumors.

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来源期刊

Neurology India 医学-神经科学

CiteScore

1.60

自引率

70.40%

发文量

434

审稿时长

2 months

期刊介绍： Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.