肌肉丰富的 microRNA-486 介导的肌肉萎缩和运动调控。

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dayong Qiu, Yan Zhang, Pinshi Ni, Zhuangzhi Wang, Luodan Yang, Fanghui Li
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引用次数: 0

摘要

本综述旨在了解microRNA-486对肌生成和肌肉萎缩的影响,以及运动后microRNA-486的变化,并为基于针对microRNA-486的运动干预改善肌肉萎缩提供有价值的信息。富含肌肉的microRNAs(miRNAs)也被称为myomiRs,它们控制着骨骼肌的各种过程,从肌生成和肌肉稳态到对环境刺激(如运动)的不同反应。MicroRNA-486是一种miRNA,其茎环序列嵌入ANKYRIN1(ANK1)基因座中,在哺乳动物中严格保守。MicroRNA-486与衰老、不运动、长期暴露于微重力环境或肌肉和神经肌肉疾病引起的肌肉萎缩有关。PI3K/AKT 信号转导是一种积极的途径,它通过增加蛋白质合成和减少蛋白质降解来增加肌肉质量。MicroRNA-486 可通过抑制磷酸酶和天丝同源物(PTEN)激活这一途径,也可间接抑制 HIPPO 信号途径,促进细胞生长。运动可调节血液和肌肉中 microRNA-486 的表达。这篇综述重点阐述了近年来microRNA-486对肌肉疏松症的调控及其对病理状态的影响,包括原发性肌肉疾病、继发性肌肉疾病和老年性肌肉疏松症。此外,还强调了运动在调节骨骼肌富集的 microRNA-486 中的作用及其生理意义。越来越多的证据表明,microRNA-486 对肌肉萎缩的发展有重大影响。microRNA-486极有可能成为通过运动干预改善肌肉萎缩的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Muscle-enriched microRNA-486-mediated regulation of muscular atrophy and exercise.

Muscle-enriched microRNA-486-mediated regulation of muscular atrophy and exercise.

The objectives of this review were to understand the impact of microRNA-486 on myogenesis and muscle atrophy, and the change of microRNA-486 following exercise, and provide valuable information for improving muscle atrophy based on exercise intervention targeting microRNA-486. Muscle-enriched microRNAs (miRNAs), also referred to as myomiRs, control various processes in skeletal muscles, from myogenesis and muscle homeostasis to different responses to environmental stimuli such as exercise. MicroRNA-486 is a miRNA in which a stem-loop sequence is embedded within the ANKYRIN1 (ANK1) locus and is strictly conserved across mammals. MicroRNA-486 is involved in the development of muscle atrophy caused by aging, immobility, prolonged exposure to microgravity, or muscular and neuromuscular disorders. PI3K/AKT signaling is a positive pathway, as it increases muscle mass by increasing protein synthesis and decreasing protein degradation. MicroRNA-486 can activate this pathway by inhibiting phosphatase and tensin homolog (PTEN), it may also indirectly inhibit the HIPPO signaling pathway to promote cell growth. Exercises regulate microRNA-486 expression both in blood and muscle. This review focused on the recent elucidation of sarcopenia regulation by microRNA-486 and its effects on pathological states, including primary muscular disease, secondary muscular disorders, and age-related sarcopenia. Additionally, the role of exercise in regulating skeletal muscle-enriched microRNA-486 was highlighted, along with its physiological significance. Growing evidence indicates that microRNA-486 significantly impacts the development of muscle atrophy. MicroRNA-486 has great potential to become a therapeutic target for improving muscle atrophy through exercise intervention.

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来源期刊
Journal of physiology and biochemistry
Journal of physiology and biochemistry 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.
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