中枢神经系统在哺乳动物衰老和长寿的细胞非自主信号机制中的作用。

IF 2.6 4区医学 Q2 PHYSIOLOGY

Journal of Physiological Sciences Pub Date : 2024-08-31 DOI:10.1186/s12576-024-00934-3

Takuya Urushihata, Akiko Satoh

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引用次数: 0

摘要

在生物体的整个生命周期中，多个器官协调维持着正常的生理功能。最近的研究发现，在一些生物体内，衰老和长寿受细胞非自主信号机制的调控。在大脑中，尤其是在下丘脑中，衰老和长寿受这种细胞非自主信号机制的调控。目前已发现几个下丘脑神经元是哺乳动物长寿的调节器，在啮齿动物模型中，操纵这些神经元可促进寿命延长或缩短寿命。下丘脑的结构和功能在物种进化中高度保守。因此，阐明下丘脑在衰老过程中的功能将揭示衰老和长寿的机制，从而有益于人类健康。

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Role of the central nervous system in cell non-autonomous signaling mechanisms of aging and longevity in mammals.

Multiple organs orchestrate the maintenance of proper physiological function in organisms throughout their lifetimes. Recent studies have uncovered that aging and longevity are regulated by cell non-autonomous signaling mechanisms in several organisms. In the brain, particularly in the hypothalamus, aging and longevity are regulated by such cell non-autonomous signaling mechanisms. Several hypothalamic neurons have been identified as regulators of mammalian longevity, and manipulating them promotes lifespan extension or shortens the lifespan in rodent models. The hypothalamic structure and function are evolutionally highly conserved across species. Thus, elucidation of hypothalamic function during the aging process will shed some light on the mechanisms of aging and longevity and, thereby benefiting to human health.

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来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.