骨钙素:识别和监测快速进展的中枢性性早熟女孩的潜在标志物。

IF 1.6 4区 医学 Q2 PEDIATRICS
Wei Qin, Yanfei Chen, Suren R Sooranna, Dan Zeng, Tao Xie, Qi Meng, Dan Lan
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引用次数: 0

摘要

目的:评估血清骨钙素(OC)作为区分速发型和非速发型中枢性性早熟(RP-CPP和NRP-CPP)的标志物的适用性,以及其评估促性腺激素释放激素激动剂(GnRHa)治疗后生长速度的潜力:方法:使用酶联免疫吸附测定法测量被诊断为 RP-CPP 或 NRP-CPP 的女孩以及正常对照组的血清 OC 水平。为确定 OC 的临界值,进行了接收者操作特征(ROC)曲线分析。多变量线性回归分析用于分析与 OC 相关的主要影响因素:结果:与正常对照组相比,CPP 女孩的血清 OC 含量更高(110.76 ± 43.69 vs 55.97 ± 20.96 ng/mL,P 结论:血清 OC 含量可作为一个重要的参考指标:血清 OC 水平可能是区分 RP-CPP 和 NRP-CPP 的有用标志物。此外,在 GnRHa 治疗期间,它还是预测生长速度的有效指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Osteocalcin: A potential marker to identify and monitor girls with rapidly progressive central precocious puberty

Aim

To evaluate the suitability of serum osteocalcin (OC) as a marker to distinguish between rapidly and non-rapidly progressive central precocious puberty (RP-CPP and NRP-CPP), as well as its potential to assess growth rates following treatment with gonadotropin-releasing hormone agonist (GnRHa).

Methods

Serum levels of OC were measured using enzyme-linked immunosorbent assays in girls diagnosed with either RP-CPP or NRP-CPP as well as in normal control subjects. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off value for OC. Multivariate linear regression analysis was used to analyse the main influencing factors associated with OC.

Results

Serum OC levels were higher in the CPP girls when compared to normal controls (110.76 ± 43.69 vs 55.97 ± 20.96 ng/mL, P < 0.001). The level in the RP-CPP group was higher than the NRP-CPP group (153.28 ± 33.89 vs 88.33 ± 29.26 ng/mL, P < 0.001). The cut-off value of OC levels for distinguishing between RP-CPP and NRP-CPP was 107.05 ng/mL, the sensitivity was 94.7% and the specificity was 77.8%, which was superior to using the basal luteinising hormone (B-LH) levels, and the area under ROC curve (AUC) were 0.933 versus 0.695, respectively. Following 1–2 years of treatment with GnRHa for girls with CPP, both OC levels and the growth rates decreased to pre-pubertal values. B-LH levels, bone age and body weight were also significant factors, which affected OC levels.

Conclusions

Serum OC levels may be a useful marker for distinguishing RP-CPP from NRP-CPP. In addition, it was also found to be a useful predictor for growth rate during GnRHa treatment.

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来源期刊
CiteScore
2.90
自引率
5.90%
发文量
487
审稿时长
3-6 weeks
期刊介绍: The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.
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