比较用于预测辐射诱发儿科白内障的剂量参数。

IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Siriphan Leangcharoensap, Kullathorn Thephamongkhol, Putthipong Chanwichu, Teeradon Treechairusame, Nan Suntornpong, Warissara Rongthong
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引用次数: 0

摘要

简介:本研究比较了晶状体最大点剂量(Lens Dmax)≥7 Gy、晶状体平均剂量(Lens Dmean)≥7 Gy、晶状体最大点剂量≥10 Gy和晶状体平均剂量≥10 Gy对辐射诱发白内障的预测能力:纳入2010年1月至2019年12月期间在我院接受头颈部颅脑照射或放射治疗的3-18岁患者。排除未进行基线和/或随访眼部检查的患者。接收者操作特征曲线(ROC)确定了潜在的预测因素,Cox回归分析了潜在因素与白内障发生之间的相关性:对 63 名患者(122 只眼睛)进行了分析。有 14 只眼睛(11.5%)发现白内障。随访时间中位数为 4 年(0.5-10 年不等),白内障发生时间中位数为 2.5 年(0.3-7 年不等)。三名患者(21.4%)发展为≥3级白内障。白内障的形成与透镜Dmean≥10 Gy有关:结论:透镜均值≥10 Gy对预测辐射诱发的儿科白内障的能力最强。净再分类改进(NRI)表明,将透镜剂量约束从Dmax
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparison of dosimetric parameters for predicting radiation-induced cataract in paediatric patients

Comparison of dosimetric parameters for predicting radiation-induced cataract in paediatric patients

Introduction

This study compared the predictive ability of radiation-induced cataract between maximum point dose of the lens (Lens Dmax) ≥7 Gy, mean lens dose (Lens Dmean) ≥7 Gy, Lens Dmax ≥10 Gy, and Lens Dmean ≥10 Gy.

Methods

Patients aged 3–18 years received cranial irradiation or radiation therapy at head and neck area between January 2010 and December 2019 at our institute were included. Patients without baseline and/or follow-up eye examination were excluded. Receiver operating characteristic (ROC) curves identified potential predictors and Cox regression analysed correlations between potential factors and cataract occurrence.

Results

Sixty-three patients (122 eyes) were analysed. Cataracts were detected in 14 eyes (11.5%). Median follow-up time was 4 years (range 0.5–10 years), with cataract developing in a median of 2.5 years (range 0.3–7 years). Three patients (21.4%) developed grade ≥3 cataract. Lens Dmean ≥10 Gy was associated with cataract formation.

Conclusion

Lens Dmean ≥10 Gy showed the highest ability for predicting radiation-induced cataract in paediatric patients. Net reclassification improvement (NRI) suggested that changing lens dose constraint from Dmax <7 Gy to Dmean <10 Gy would miss 7% of cataract cases but avoid 28% of unnecessary restrictions. Adopting a mean lens dose <10 Gy was suggested as a constraint for lens dose.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
133
审稿时长
6-12 weeks
期刊介绍: Journal of Medical Imaging and Radiation Oncology (formerly Australasian Radiology) is the official journal of The Royal Australian and New Zealand College of Radiologists, publishing articles of scientific excellence in radiology and radiation oncology. Manuscripts are judged on the basis of their contribution of original data and ideas or interpretation. All articles are peer reviewed.
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