Sana Mohammadi, Sadegh Ghaderi, Hossein Mohammadi, Farzad Fatehi
{"title":"作为早期帕金森病 MRI 神经影像生物标志物的黑质下平均易感度和平均峰度的同时增加：系统回顾与元分析》。","authors":"Sana Mohammadi, Sadegh Ghaderi, Hossein Mohammadi, Farzad Fatehi","doi":"10.1002/jmri.29569","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression.</p><p><strong>Hypothesis: </strong>Simultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early-stage PD (ESPD) in the basal ganglia nuclei, including the substantia nigra (SN), putamen (PUT), globus pallidus (GP), and caudate nucleus (CN).</p><p><strong>Study type: </strong>Systematic review and meta-analysis.</p><p><strong>Population: </strong>One hundred eleven patients diagnosed with ESPD and 81 healthy controls (HCs) were included from four studies that utilized both QSM and DKI in both subject groups.</p><p><strong>Field strength/sequence: </strong>Three-dimensional multi-echo gradient echo sequence for QSM and spin echo planar imaging sequence for DKI at 3 Tesla.</p><p><strong>Assessment: </strong>A systematic review and meta-analysis using PRISMA guidelines searched PubMed, Web of Science, and Scopus.</p><p><strong>Statistical tests: </strong>Random-effects model, standardized mean difference (SMD) to compare MS and MK between ESPD patients and HCs, I<sup>2</sup> statistic for heterogeneity, Newcastle-Ottawa Scale (NOS) for risk of bias, and Egger's test for publication bias. A P-value <0.05 was considered significant.</p><p><strong>Results: </strong>MS values were significantly higher in SN (SMD 0.72, 95% CI 0.31 to 1.12), PUT (SMD 0.68, 95% CI 0.29 to 1.07), and GP (SMD 0.53, 95% CI 0.19 to 0.87) in ESPD patients compared to HCs. CN did not show a significant difference in MS values (P = 0.15). MK values were significantly higher only in SN (SMD = 0.72, 95% CI 0.16 to 1.27). MK values were not significantly different in PUT (P = 1.00), GP (P = 0.97), and CN (P = 0.59). Studies had high quality (NOS 7-8) and no publication bias (P = 0.967).</p><p><strong>Data conclusion: </strong>Simultaneous use of MS and MK may be useful as an early neuroimaging biomarker for ESPD detection and its differentiation from HCs, with significant differences observed in the SN.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early-Stage Parkinson's Disease: A Systematic Review and Meta-Analysis.\",\"authors\":\"Sana Mohammadi, Sadegh Ghaderi, Hossein Mohammadi, Farzad Fatehi\",\"doi\":\"10.1002/jmri.29569\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression.</p><p><strong>Hypothesis: </strong>Simultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early-stage PD (ESPD) in the basal ganglia nuclei, including the substantia nigra (SN), putamen (PUT), globus pallidus (GP), and caudate nucleus (CN).</p><p><strong>Study type: </strong>Systematic review and meta-analysis.</p><p><strong>Population: </strong>One hundred eleven patients diagnosed with ESPD and 81 healthy controls (HCs) were included from four studies that utilized both QSM and DKI in both subject groups.</p><p><strong>Field strength/sequence: </strong>Three-dimensional multi-echo gradient echo sequence for QSM and spin echo planar imaging sequence for DKI at 3 Tesla.</p><p><strong>Assessment: </strong>A systematic review and meta-analysis using PRISMA guidelines searched PubMed, Web of Science, and Scopus.</p><p><strong>Statistical tests: </strong>Random-effects model, standardized mean difference (SMD) to compare MS and MK between ESPD patients and HCs, I<sup>2</sup> statistic for heterogeneity, Newcastle-Ottawa Scale (NOS) for risk of bias, and Egger's test for publication bias. A P-value <0.05 was considered significant.</p><p><strong>Results: </strong>MS values were significantly higher in SN (SMD 0.72, 95% CI 0.31 to 1.12), PUT (SMD 0.68, 95% CI 0.29 to 1.07), and GP (SMD 0.53, 95% CI 0.19 to 0.87) in ESPD patients compared to HCs. CN did not show a significant difference in MS values (P = 0.15). MK values were significantly higher only in SN (SMD = 0.72, 95% CI 0.16 to 1.27). MK values were not significantly different in PUT (P = 1.00), GP (P = 0.97), and CN (P = 0.59). Studies had high quality (NOS 7-8) and no publication bias (P = 0.967).</p><p><strong>Data conclusion: </strong>Simultaneous use of MS and MK may be useful as an early neuroimaging biomarker for ESPD detection and its differentiation from HCs, with significant differences observed in the SN.</p><p><strong>Evidence level: </strong>2 TECHNICAL EFFICACY: Stage 2.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.29569\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.29569","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
背景：帕金森病（PD）是第二大最常见的神经退行性疾病。早期发现对于治疗和延缓疾病进展至关重要：假设：定量易感性图谱（QSM）中平均易感性（MS）和弥散峰度成像（DKI）中平均峰度（MK）的同时改变可作为早期帕金森病（ESPD）在黑质（SN）、普鲁门（PUT）、苍白球（GP）和尾状核（CN）等基底神经节核团中的可靠神经影像生物标志物：研究类型：系统回顾和荟萃分析：纳入了四项研究中的 111 名确诊为 ESPD 的患者和 81 名健康对照组（HCs），这四项研究在两组受试者中均使用了 QSM 和 DKI：场强/序列：QSM采用三维多回波梯度回波序列，DKI采用3特斯拉自旋回波平面成像序列：采用PRISMA指南对PubMed、Web of Science和Scopus进行了系统回顾和荟萃分析：随机效应模型、比较ESPD患者和HC之间MS和MK的标准化平均差（SMD）、异质性的I2统计量、偏倚风险的纽卡斯尔-渥太华量表（NOS）和发表偏倚的Egger检验。A P值 结果：ESPD患者的SN（SMD为0.72，95% CI为0.31至1.12）、PUT（SMD为0.68，95% CI为0.29至1.07）和GP（SMD为0.53，95% CI为0.19至0.87）的MS值明显高于HC。CN在MS值上没有显示出明显差异（P = 0.15）。只有SN的MK值明显较高（SMD = 0.72，95% CI 0.16至1.27）。MK值在PUT（P = 1.00）、GP（P = 0.97）和CN（P = 0.59）中无明显差异。研究质量高（NOS 7-8），无发表偏倚（P = 0.967）：数据结论：同时使用 MS 和 MK 可作为早期神经影像生物标志物，用于检测 ESPD 并将其与 HC 区分开来，在 SN 中可观察到显著差异。
Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early-Stage Parkinson's Disease: A Systematic Review and Meta-Analysis.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression.
Hypothesis: Simultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early-stage PD (ESPD) in the basal ganglia nuclei, including the substantia nigra (SN), putamen (PUT), globus pallidus (GP), and caudate nucleus (CN).
Study type: Systematic review and meta-analysis.
Population: One hundred eleven patients diagnosed with ESPD and 81 healthy controls (HCs) were included from four studies that utilized both QSM and DKI in both subject groups.
Field strength/sequence: Three-dimensional multi-echo gradient echo sequence for QSM and spin echo planar imaging sequence for DKI at 3 Tesla.
Assessment: A systematic review and meta-analysis using PRISMA guidelines searched PubMed, Web of Science, and Scopus.
Statistical tests: Random-effects model, standardized mean difference (SMD) to compare MS and MK between ESPD patients and HCs, I2 statistic for heterogeneity, Newcastle-Ottawa Scale (NOS) for risk of bias, and Egger's test for publication bias. A P-value <0.05 was considered significant.
Results: MS values were significantly higher in SN (SMD 0.72, 95% CI 0.31 to 1.12), PUT (SMD 0.68, 95% CI 0.29 to 1.07), and GP (SMD 0.53, 95% CI 0.19 to 0.87) in ESPD patients compared to HCs. CN did not show a significant difference in MS values (P = 0.15). MK values were significantly higher only in SN (SMD = 0.72, 95% CI 0.16 to 1.27). MK values were not significantly different in PUT (P = 1.00), GP (P = 0.97), and CN (P = 0.59). Studies had high quality (NOS 7-8) and no publication bias (P = 0.967).
Data conclusion: Simultaneous use of MS and MK may be useful as an early neuroimaging biomarker for ESPD detection and its differentiation from HCs, with significant differences observed in the SN.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
