快讯前列腺癌筛查：是时候采用新方法了吗？评论文章。

IF 2.5 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of Investigative Medicine Pub Date : 2025-01-01 Epub Date: 2024-10-15 DOI:10.1177/10815589241279414

Christopher James Mikulas, Kabeer Ali, Nirmal Onteddu

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引用次数: 0

摘要

前列腺癌筛查是临床医生面临的一项挑战。虽然前列腺特异性抗原（PSA）和数字直肠检查（DRE）等筛查方法的实施对前列腺癌的死亡率产生了重大影响，但这些传统筛查方法对有临床意义的前列腺癌（CSPC）的阳性预测值相对较低，从而导致不必要的活检和治疗，并带来一系列潜在并发症。幸运的是，有关这一主题的许多研究已经完成并正在进行中。其中包括前列腺癌、肺癌、结肠直肠癌和卵巢癌筛查试验（Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial）和 IP1-PROSTAGRAM 试验（IP1-PROSTAGRAM Trial），前者进行了二次分析以确定 PSA 水平与 CSPC 之间的关联，后者评估了多参数磁共振成像（mpMRI）在前列腺癌筛查中的功效。这些研究对确定适当的 PSA 临界值、DRE 的正确使用以及磁共振成像在最大限度地提高 CSPC 诊断率的同时减少不必要的活检或治疗所展示的前景等方面都有极大的帮助。

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Prostate cancer screening: Is it time for a new approach? A review article.

Prostate cancer screening has presented a challenge to clinicians. Although the implementation of screening tests such as prostate-specific antigen (PSA) and digital rectal exam (DRE) has had a significant impact on prostate-cancer-specific mortality, these traditional screening tests have a relatively poor positive predictive value of clinically significant prostate cancer (CSPC), leading to unnecessary biopsies and treatment with a host of potential complications. Fortunately, much research has been done to optimize prostate cancer screening. This includes the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, which underwent a secondary analysis to identify an association between PSA level and CSPC, and the IP1-PROSTAGRAM Tri.

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来源期刊

Journal of Investigative Medicine 医学-医学：内科

CiteScore

4.90

自引率

0.00%

发文量

111

审稿时长

24 months

期刊介绍： Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research. JIM publishes on all topics and specialty areas that are critical to the conduct of the entire spectrum of biomedical research: from the translation of clinical observations at the bedside, to basic and animal research to clinical research and the implementation of innovative medical care.