右心室及其肺血管相互作用的病理生理学。

IF 16.6 1区 医学 Q1 RESPIRATORY SYSTEM
European Respiratory Journal Pub Date : 2024-10-31 Print Date: 2024-10-01 DOI:10.1183/13993003.01321-2024
Anna R Hemnes, David S Celermajer, Michele D'Alto, Francois Haddad, Paul M Hassoun, Kurt W Prins, Robert Naeije, Anton Vonk Noordegraaf
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引用次数: 0

摘要

右心室及其应激反应可能是多种原因导致的肺动脉高压患者存活的最重要决定因素。2018 年世界肺动脉高压研讨会上提出的心肺单元生理学和右心衰竭定义在随后几年被证明是有用的构建。在此,我们回顾了在健康和疾病中驱动右心室功能的基本机制的最新知识,这些知识可能对未来的治疗干预有用。我们进一步介绍了评估右心室功能的新知识,重点是临床医生可随时使用的指标,以及对右心房和三尖瓣反流作用的最新认识。回顾了相关肺血管疾病的典型右心室表型,并讨论了近期对慢性右心室衰竭的药物干预研究。最后,提出了未解之谜和未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathophysiology of the right ventricle and its pulmonary vascular interaction.

The right ventricle and its stress response is perhaps the most important arbiter of survival in patients with pulmonary hypertension of many causes. The physiology of the cardiopulmonary unit and definition of right heart failure proposed in the 2018 World Symposium on Pulmonary Hypertension have proven useful constructs in subsequent years. Here, we review updated knowledge of basic mechanisms that drive right ventricular function in health and disease, and which may be useful for therapeutic intervention in the future. We further contextualise new knowledge on assessment of right ventricular function with a focus on metrics readily available to clinicians and updated understanding of the roles of the right atrium and tricuspid regurgitation. Typical right ventricular phenotypes in relevant forms of pulmonary vascular disease are reviewed and recent studies of pharmacological interventions on chronic right ventricular failure are discussed. Finally, unanswered questions and future directions are proposed.

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来源期刊
European Respiratory Journal
European Respiratory Journal 医学-呼吸系统
CiteScore
27.50
自引率
3.30%
发文量
345
审稿时长
2-4 weeks
期刊介绍: The European Respiratory Journal (ERJ) is the flagship journal of the European Respiratory Society. It has a current impact factor of 24.9. The journal covers various aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine, and thoracic surgery. In addition to original research material, the ERJ publishes editorial commentaries, reviews, short research letters, and correspondence to the editor. The articles are published continuously and collected into 12 monthly issues in two volumes per year.
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