Jeremy Anderson, Lien Anh Ha Do, Puck B van Kasteren, Paul V Licciardi
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引用次数: 0
摘要
严重呼吸道合胞病毒(RSV)疾病是造成全球婴幼儿疾病负担的一个重要因素。研究表明,RSV 附着蛋白 (G) 通过其 CX3C 基序与宿主受体 CX3CR1 相互作用,对入侵气道上皮细胞至关重要。这种受体在免疫细胞中的普遍表达可能是它们易受 RSV 感染的原因。RSV G 蛋白可能会通过对正常细胞功能的重编程,导致抗病毒反应受到抑制,从而加重疾病的严重程度。虽然针对 RSV 融合(F)蛋白的现有预防药物非常有效,但目前还没有基于 G 蛋白的 RSV 治疗药物来限制 RSV 的致病机理。以 RSV G 蛋白为靶点的单克隆抗体作为小鼠感染后的治疗药物,已被证明可以改善抗病毒反应、减少病毒载量并限制疾病的严重程度。要更好地了解 RSV 感染免疫细胞是如何导致发病的,还需要进一步的研究,以便开发出更有针对性和更有效的疗法。
The role of respiratory syncytial virus G protein in immune cell infection and pathogenesis.
Severe respiratory syncytial virus (RSV) disease is a significant contributor to the global burden of disease in infants and children. The RSV attachment protein (G) has been shown to be critical in invading airway epithelial cells through its CX3C motif interacting with the host receptor CX3CR1. The ubiquitous expression of this receptor on immune cells may explain their susceptibility to RSV infection. The RSV G protein may enhance disease severity through reprogramming of normal cellular functionality leading to inhibition of antiviral responses. While existing preventives targeting the RSV fusion (F) protein are highly effective, there are no RSV therapeutics based on the G protein to limit RSV pathogenesis. Monoclonal antibodies targeting the RSV G protein administered as post-infection therapeutics in mice have been shown to improve the antiviral response, reduce viral load and limit disease severity. Further research is required to better understand how RSV infection of immune cells contributes to pathogenesis for the development of more targeted and efficacious therapeutics.
EBioMedicineBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍:
eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.