{"title":"转录调节因子ID3能在肿瘤发生过程中维持引流淋巴结中的肿瘤特异性记忆CD8+T细胞。","authors":"Ling Ran, Zhengliang Yue, Mengqu Ran, Qiao Liu, Xingxing Su, Lisha Wang, Shuqiong Wen, Luming Xu, Shun Lei, Zhanpeng Ou, Jianjun Hu, Yan Zhang, Chenxi Qin, Yuzhu Wang, Qinyi He, Yezi Chen, Wen Liu, Lilin Ye, Qizhao Huang, Lifan Xu","doi":"10.1016/j.celrep.2024.114690","DOIUrl":null,"url":null,"abstract":"<p><p>During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-T<sub>TSM</sub> cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (T<sub>PEX</sub>) cells and further replenishes tumor-specific CD8<sup>+</sup> T cells residing in the tumor microenvironment (TME). However, how T<sub>TSM</sub> cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by T<sub>TSM</sub> cells compared with other CD8<sup>+</sup> T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of T<sub>TSM</sub> and T<sub>PEX</sub> cells, resulting in decreased tumor-infiltrating CD8<sup>+</sup> T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8<sup>+</sup> T cells increases the T<sub>TSM</sub> cell population and enhances the anti-tumor immune response.</p>","PeriodicalId":9798,"journal":{"name":"Cell reports","volume":null,"pages":null},"PeriodicalIF":7.5000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The transcription regulator ID3 maintains tumor-specific memory CD8<sup>+</sup> T cells in draining lymph nodes during tumorigenesis.\",\"authors\":\"Ling Ran, Zhengliang Yue, Mengqu Ran, Qiao Liu, Xingxing Su, Lisha Wang, Shuqiong Wen, Luming Xu, Shun Lei, Zhanpeng Ou, Jianjun Hu, Yan Zhang, Chenxi Qin, Yuzhu Wang, Qinyi He, Yezi Chen, Wen Liu, Lilin Ye, Qizhao Huang, Lifan Xu\",\"doi\":\"10.1016/j.celrep.2024.114690\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-T<sub>TSM</sub> cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (T<sub>PEX</sub>) cells and further replenishes tumor-specific CD8<sup>+</sup> T cells residing in the tumor microenvironment (TME). However, how T<sub>TSM</sub> cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by T<sub>TSM</sub> cells compared with other CD8<sup>+</sup> T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of T<sub>TSM</sub> and T<sub>PEX</sub> cells, resulting in decreased tumor-infiltrating CD8<sup>+</sup> T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8<sup>+</sup> T cells increases the T<sub>TSM</sub> cell population and enhances the anti-tumor immune response.</p>\",\"PeriodicalId\":9798,\"journal\":{\"name\":\"Cell reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.5000,\"publicationDate\":\"2024-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell reports\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.celrep.2024.114690\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell reports","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.celrep.2024.114690","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
在肿瘤发生过程中,最近发现的引流淋巴结中的肿瘤特异性记忆 T 细胞(TdLN-TTSM 细胞)在肿瘤抑制过程中发挥了关键作用,这种抑制产生了原代衰竭 T(TPEX)细胞,并进一步补充了驻留在肿瘤微环境(TME)中的肿瘤特异性 CD8+ T 细胞。然而,TTSM 细胞是如何在 TdLN 中维持的目前还不清楚。在这里,我们发现与其他 CD8+ T 细胞亚群相比,TTSM 细胞高度表达转录调节因子 ID3(DNA 结合抑制因子 3)。ID3 的缺乏会明显干扰 TTSM 和 TPEX 细胞的维持,导致肿瘤浸润性 CD8+ T 细胞减少,肿瘤控制能力受损。与此相一致的是,在 CD8+ T 细胞中过表达 ID3 会增加 TTSM 细胞数量并增强抗肿瘤免疫反应。
The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis.
During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-TTSM cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (TPEX) cells and further replenishes tumor-specific CD8+ T cells residing in the tumor microenvironment (TME). However, how TTSM cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by TTSM cells compared with other CD8+ T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of TTSM and TPEX cells, resulting in decreased tumor-infiltrating CD8+ T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8+ T cells increases the TTSM cell population and enhances the anti-tumor immune response.
期刊介绍:
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