Wonyeong Jung, Arturo Abdelnour, Paulina Kaplonek, Rolando Herrero, Jessica Shih-Lu Lee, Domenic R Barbati, Taras M Chicz, Kate S Levine, Romain Clement Fantin, Viviana Loria, Carolina Porras, Douglas A Lauffenburger, Mitchell H Gail, Amada Aparicio, Allan Hildesheim, Galit Alter, Ryan P McNamara
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引用次数: 0
摘要
感染后通过接种疫苗获得的免疫力被称为混合免疫力,已被证明可通过提高免疫反应的广度和效力来增强对严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)的保护。在此,我们对混合免疫中 Fc 介导的体液特征及其与年龄和疫苗类型的关系进行了评估。参与者分为三组:仅感染组、仅接种组和感染后接种组(即混合免疫组)。我们利用系统血清学分析了针对 SARS-CoV-2 变体的尖峰和亚域的体液免疫反应。我们发现,混合免疫的特点是超强的 Fc 受体结合力以及自然杀伤(NK)细胞、中性粒细胞和补体激活抗体,这高于疫苗接种和感染的总和。混合免疫和疫苗诱导免疫之间的这些差异在老年人中更为明显,尤其是免疫球蛋白(Ig)G1、IgG2 和 Fcγ 受体结合抗体。我们的研究结果表明,旨在模拟混合免疫的疫苗接种策略应将年龄作为一个重要的调节因素。
SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner.
Immunity acquired by vaccination following infection, termed hybrid immunity, has been shown to confer enhanced protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by enhancing the breadth and potency of immune responses. Here, we assess Fc-mediated humoral profiles in hybrid immunity and their association with age and vaccine type. Participants are divided into three groups: infection only, vaccination only, and vaccination following infection (i.e., hybrid immunity). Using systems serology, we profile humoral immune responses against spikes and subdomains of SARS-CoV-2 variants. We find that hybrid immunity is characterized by superior Fc receptor binding and natural killer (NK) cell-, neutrophil-, and complement-activating antibodies, which is higher than what can be expected from the sum of the vaccination and infection. These differences between hybrid immunity and vaccine-induced immunity are more pronounced in aged adults, especially for immunoglobulin (Ig)G1, IgG2, and Fcγ receptor-binding antibodies. Our findings suggest that vaccination strategies that aim to mimic hybrid immunity should consider age as an important modifier.
期刊介绍:
Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted.
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