液体活检:为癌症研究开辟新途径

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI:10.1080/19336918.2024.2395807
Keerthi Kurma, Zahra Eslami-S, Catherine Alix-Panabières, Laure Cayrefourcq
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引用次数: 0

摘要

目前,癌症诊断和分子图谱分析依赖于侵入性组织活检或临床成像,这些限制因素推动了液体活检领域的兴起。液体活检包括从体液样本中提取循环肿瘤细胞(CTCs)、循环游离或循环肿瘤 DNA(cfDNA 或 ctDNA)、循环无细胞 RNA(cfRNA)、细胞外囊泡(EVs)和肿瘤教育血小板(TEPs)。随后,对这些成分进行分子表征,以确定对早期癌症检测、预后判断、治疗评估和治疗后监测至关重要的生物标记物。这些创新的生物资源所表现出的特征与原发肿瘤的特征相似,而原发肿瘤正是这些生物资源的来源或相互作用的对象。本综述全面探讨了处理这些生物资源所采用的各种技术和方法及其主要临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liquid biopsy: paving a new avenue for cancer research.

The current constraints associated with cancer diagnosis and molecular profiling, which rely on invasive tissue biopsies or clinical imaging, have spurred the emergence of the liquid biopsy field. Liquid biopsy involves the extraction of circulating tumor cells (CTCs), circulating free or circulating tumor DNA (cfDNA or ctDNA), circulating cell-free RNA (cfRNA), extracellular vesicles (EVs), and tumor-educated platelets (TEPs) from bodily fluid samples. Subsequently, these components undergo molecular characterization to identify biomarkers that are critical for early cancer detection, prognosis, therapeutic assessment, and post-treatment monitoring. These innovative biosources exhibit characteristics analogous to those of the primary tumor from which they originate or interact. This review comprehensively explores the diverse technologies and methodologies employed for processing these biosources, along with their principal clinical applications.

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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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