社会、行为和临床风险因素与克隆性造血有关。

IF 3.7 3区 医学 Q2 ONCOLOGY
Corey D Young, Aubrey K Hubbard, Pedro F Saint-Maurice, Irenaeus C C Chan, Yin Cao, Duc Tran, Kelly L Bolton, Stephen J Chanock, Charles E Matthews, Steven C Moore, Erikka Loftfield, Mitchell J Machiela
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引用次数: 0

摘要

背景:吸烟、饮酒、体力活动(PA)和睡眠模式等风险因素与癌症风险有关。克隆性造血(CH),包括镶嵌染色体改变(mCAs)和不确定潜能的克隆性造血(CHIP),与造血癌症风险增加有关,可作为常见的临床前中间体,用于更好地了解风险因素与罕见血液恶性肿瘤的关联:我们使用多变量调整分析法分析了478513名未患血液系统恶性肿瘤的英国生物库参与者的横截面数据,以评估生活方式因素与CH类型之间的关联:结果发现:吸烟是导致多种类型癌症的一个强有力的可改变的风险因素,其剂量依赖关系在戒烟后仍然存在。英格兰社会贫困地区的男性发生 Y 染色体马赛克缺失(mLOY)的风险较低;与轻度/高度饮酒(每天 2-3 杯)的女性相比,发生 mLOX 的风险增加(OR=1.17,95%CI:[1.09-1.25],p=8.与轻度饮酒者相比,活跃男性(中度-高度 PA)的 mLOY 风险升高(PA 类别 3:OR=1.06,95%CI:[1.03-1.08],p=7.57×10-6),高 BMI(≥40)男性的 mLOY 风险降低(OR=0.57,95%CI:[0.51-0.65],p=3.30×10-20)。调整体重指数的敏感性分析削弱了 mLOY-PA 关联的影响(IPAQ2:OR=1.03,95%CI:[1.00-1.06],p=2.13×10-2;IPAQ3:OR=1.03,95%CI:[1.01-1.06],p=7.77×10-3):我们的研究揭示了社会贫困、吸烟、饮酒与CH风险之间的关联,表明这些暴露可能导致常见类型的CH和潜在的罕见血液癌症:本研究强调了生活方式因素对CH发病率的影响,强调了社会、行为和临床影响,以及在调查CH风险因素时社会行为背景的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Social, Behavioral, and Clinical Risk Factors Are Associated with Clonal Hematopoiesis.

Background: Risk factors including smoking, alcohol intake, physical activity (PA), and sleep patterns have been associated with cancer risk. Clonal hematopoiesis (CH), including mosaic chromosomal alterations and clonal hematopoiesis of indeterminate potential, is linked to increased hematopoietic cancer risk and could be used as common preclinical intermediates for the better understanding of associations of risk factors with rare hematologic malignancies.

Methods: We analyzed cross-sectional data from 478,513 UK Biobank participants without hematologic malignancies using multivariable-adjusted analyses to assess the associations between lifestyle factors and CH types.

Results: Smoking was reinforced as a potent modifiable risk factor for multiple CH types, with dose-dependent relationships persisting after cessation. Males in socially deprived areas of England had a lower risk of mosaic loss of chromosome Y (mLOY), females with moderate/high alcohol consumption (2-3 drinks/day) had increased mosaic loss of the X chromosome risk [OR = 1.17; 95% confidence interval (CI), 1.09-1.25; P = 8.31 × 10-6] compared with light drinkers, active males (moderate-high PA) had elevated risks of mLOY (PA category 3: OR = 1.06; 95% CI, 1.03-1.08; P = 7.57 × 10-6), and men with high body mass index (≥40) had reduced risk of mLOY (OR = 0.57; 95% CI, 0.51-0.65; P = 3.30 × 10-20). Sensitivity analyses with body mass index adjustment attenuated the effect in the mLOY-PA associations (IPAQ2: OR = 1.03; 95% CI, 1.00-1.06; P = 2.13 × 10-2 and IPAQ3: OR = 1.03; 95% CI, 1.01-1.06; P = 7.77 × 10-3).

Conclusions: Our study reveals associations between social deprivation, smoking, and alcohol consumption and CH risk, suggesting that these exposures could contribute to common types of CH and potentially rare hematologic cancers.

Impact: This study underscores the impact of lifestyle factors on CH frequency, emphasizing social, behavioral, and clinical influences and the importance of sociobehavioral contexts when investigating CH risk factors.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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