德国的一项回顾性队列研究:乳腺炎与乳腺癌之间是否存在关联?

IF 2.2 4区 医学 Q3 ONCOLOGY
Cancer Causes & Control Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI:10.1007/s10552-024-01909-w
Vedanth D Krishnan, Karel Kostev, Matthias Kalder
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引用次数: 0

摘要

目的:该研究旨在探讨乳腺炎与后续乳腺癌之间的关系:这项回顾性队列研究纳入了 2005 年 1 月至 2021 年 12 月期间德国 315 名妇科医生诊室中初次诊断为乳腺炎的 18 岁以上女性。根据年龄、指数年、随访期间的年均就诊频率以及并存疾病(如肥胖、良性乳腺发育不良、乳腺肥大、乳腺不明肿块和其他乳腺疾病),采用倾向得分匹配法将未患乳腺炎的女性与患乳腺炎的女性进行配对。采用对数秩检验法,以 Kaplan-Meier 曲线研究了乳腺炎队列和非乳腺炎队列的 10 年乳腺癌累积发病率。通过单变量考克斯回归分析,分别研究了四个年龄组的乳腺炎与乳腺癌之间的关系:结果:在发病日期后 7 个月至 10 年的随访期间,2.9% 的乳腺炎患者和 2.4% 的非乳腺炎患者被确诊为乳腺癌。Cox 回归分析显示,乳腺炎与随后的乳腺癌之间存在显著关联(HR:1.37;95% CI:1.11-1.70)。根据年龄分层分析,只有年龄大于 50 岁的人群才与乳腺炎有显著联系(HR:1.73;95% 1.25-2.40):我们的回顾性队列研究结果支持乳腺炎与年龄大于 50 岁的妇女随后被诊断为乳腺癌之间存在关联。然而,病理生理学基础和混杂因素的可能性还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Is there an association between mastitis and breast cancer? a retrospective cohort study from Germany.

Is there an association between mastitis and breast cancer? a retrospective cohort study from Germany.

Purpose: The aim of the study was to explore the association between mastitis and subsequent breast cancer.

Methods: This retrospective cohort study included women aged ≥ 18 years with an initial mastitis diagnosis from 315 office-based gynecologists in Germany between January 2005 and December 2021. Women without mastitis were matched to women with mastitis using propensity score matching based on age, index year, average yearly consultation frequency during the follow-up period, and coexisting diseases such as obesity, benign mammary dysplasia, hypertrophy of the breast, unspecified lump of breast, and other disorders of the breast. The 10-year cumulative incidence of breast cancer for the mastitis-cohort and non-mastitis-cohort was studied with Kaplan-Meier curves using the log-rank test. The association between mastitis and breast cancer was studied separately for four age groups with univariable Cox regression analyses.

Results: In the follow-up period of 7 months to 10 years after the index date, 2.9% of mastitis patients and 2.4% of matched non-mastitis patients were diagnosed with breast cancer. A Cox regression analysis revealed a significant association between mastitis and subsequent breast cancer (HR: 1.37; 95% CI: 1.11-1.70). According to the age-stratified analyses, a strong and significant association was only observed in the age group > 50 years (HR: 1.73; 95% 1.25-2.40).

Conclusion: The findings of our retrospective cohort study support an association between mastitis and subsequent breast cancer diagnoses in women aged > 50 years. The pathophysiological basis and possibility of confounders however requires further investigation.

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来源期刊
Cancer Causes & Control
Cancer Causes & Control 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.90
自引率
4.30%
发文量
130
审稿时长
6.6 months
期刊介绍: Cancer Causes & Control is an international refereed journal that both reports and stimulates new avenues of investigation into the causes, control, and subsequent prevention of cancer. By drawing together related information published currently in a diverse range of biological and medical journals, it has a multidisciplinary and multinational approach. The scope of the journal includes: variation in cancer distribution within and between populations; factors associated with cancer risk; preventive and therapeutic interventions on a population scale; economic, demographic, and health-policy implications of cancer; and related methodological issues. The emphasis is on speed of publication. The journal will normally publish within 30 to 60 days of acceptance of manuscripts. Cancer Causes & Control publishes Original Articles, Reviews, Commentaries, Opinions, Short Communications and Letters to the Editor which will have direct relevance to researchers and practitioners working in epidemiology, medical statistics, cancer biology, health education, medical economics and related fields. The journal also contains significant information for government agencies concerned with cancer research, control and policy.
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