鲸目动物中多效神经肽受体基因偶联的变化。

IF 4.4 1区 生物学 Q1 BIOLOGY
Raul Valente, Miguel Cordeiro, Bernardo Pinto, André Machado, Filipe Alves, Isabel Sousa-Pinto, Raquel Ruivo, L Filipe C Castro
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引用次数: 0

摘要

背景:生境转换对生物体的稳态具有相当大的影响,因为这需要同时调整几个生理区系,以保持稳定并适应不断变化的环境。在一系列对不同生理过程的调控起关键作用的分子中,神经肽是关键的媒介。在这里,我们研究了鲸目动物中几种神经肽及其受体的编码状况,这些神经肽及其受体具有多重活性:结果:对包括 41 种鲸目动物在内的 202 个哺乳动物基因组的分析显示,基因序列的改变和丢失导致了错综复杂的突变。具体到鲸目动物,在分析的 12 个基因中,我们确定了从物种特异性破坏性突变(如神经肽 FF-酰胺肽前体;NPFF)到整个鲸目动物干系基因的完全侵蚀(如体生长激素受体 4;SSTR4)不等的丢失模式:结论:这些神经调节剂中的一些受损可能是导致这组标志性哺乳动物表现出独特的能量代谢、昼夜节律和潜水反应的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alterations of pleiotropic neuropeptide-receptor gene couples in Cetacea.

Background: Habitat transitions have considerable consequences in organism homeostasis, as they require the adjustment of several concurrent physiological compartments to maintain stability and adapt to a changing environment. Within the range of molecules with a crucial role in the regulation of different physiological processes, neuropeptides are key agents. Here, we examined the coding status of several neuropeptides and their receptors with pleiotropic activity in Cetacea.

Results: Analysis of 202 mammalian genomes, including 41 species of Cetacea, exposed an intricate mutational landscape compatible with gene sequence modification and loss. Specifically for Cetacea, in the 12 genes analysed we have determined patterns of loss ranging from species-specific disruptive mutations (e.g. neuropeptide FF-amide peptide precursor; NPFF) to complete erosion of the gene across the cetacean stem lineage (e.g. somatostatin receptor 4; SSTR4).

Conclusions: Impairment of some of these neuromodulators may have contributed to the unique energetic metabolism, circadian rhythmicity and diving response displayed by this group of iconic mammals.

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来源期刊
BMC Biology
BMC Biology 生物-生物学
CiteScore
7.80
自引率
1.90%
发文量
260
审稿时长
3 months
期刊介绍: BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.
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