{"title":"一种新型神经肿瘤学氨基酸 PET 示踪剂：[18F]氟昔洛韦的模型试验程序。","authors":"Kaede Tsuzura, Kei Wagatsuma, Yuto Kamitaka, Kenta Miwa, Noriaki Miyaji, Takashi Kamiya, Noriyo Yokotsuka, Kenji Ishii","doi":"10.1007/s12149-024-01973-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Amino acid positron emission tomography (PET) examinations using anti-1-amino-3-[<sup>18</sup>F]-fluorocyclobutane-1-carboxylic acid ([<sup>18</sup>F]FACBC) were allowed for routine clinical use in July 2024. However, phantom test procedures for [<sup>18</sup>F]FACBC reconstruction parameters have not yet been established. The present study aimed to establish new phantom test procedures for [<sup>18</sup>F]FACBC brain PET imaging to determine optimal reconstruction parameters.</p><p><strong>Methods: </strong>Background (BG) activity as well as hot sphere and target-to-background ratios (TBRs) of [<sup>18</sup>F]FACBC were estimated based on brain activity and tumor-to-normal tissue ratios (TNR) in a Japanese clinical trial of [<sup>18</sup>F]FACBC. Phantom experiments proceeded under [<sup>18</sup>F]FACBC or L-[methyl-<sup>11</sup>C]-methionine ([<sup>11</sup>C]MET) conditions. The number of iterations and the Gaussian filter parameters were determined from the reconstruction parameters %contrast<sub>mean</sub> and coefficients of variation (CVs) in ordered subset expectation maximization (OSEM) and time-of-flight (TOF) with or without point-spread-function (PSF) correction.</p><p><strong>Results: </strong>The amounts of activity in the hot spheres and BG were 1.1 and 5.5 kBq/mL, respectively, and the TBR was 5.0 at the start of acquisition. The %contrast<sub>mean</sub> of all hot spheres was higher with [<sup>18</sup>F]FACBC than [<sup>11</sup>C]MET, and %contrast<sub>mean</sub> converged between 4 and 6 iterations in hot spheres with diameters < 10 mm. We used four iterations for OSEM + TOF and five for OSEM + TOF + PSF correction for [<sup>18</sup>F]FACBC and [<sup>11</sup>C]MET images. The CV was higher for [<sup>18</sup>F]FACBC than [<sup>11</sup>C]MET. The optimal sizes of Gaussian filters for OSEM + TOF and OSEM + TOF + PSF correction of image reconstruction were 5 mm for [<sup>18</sup>F]FACBC, and 4 and 3 mm, respectively, for [<sup>11</sup>C]MET images.</p><p><strong>Conclusions: </strong>We estimated phantom activity and TBR based on brain activity in a Japanese clinical trial and established new phantom test procedures for [<sup>18</sup>F]FACBC. We recommend that the optimal reconstruction parameters for [<sup>18</sup>F]FACBC should be set to the same number of iterations as [<sup>11</sup>C]MET and that the FWHM of Gaussian filter should have a few mm higher than [<sup>11</sup>C]MET to reduce image noise from brain normal tissue.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phantom test procedures for a new neuro-oncological amino acid PET tracer: [<sup>18</sup>F]fluciclovine.\",\"authors\":\"Kaede Tsuzura, Kei Wagatsuma, Yuto Kamitaka, Kenta Miwa, Noriaki Miyaji, Takashi Kamiya, Noriyo Yokotsuka, Kenji Ishii\",\"doi\":\"10.1007/s12149-024-01973-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Amino acid positron emission tomography (PET) examinations using anti-1-amino-3-[<sup>18</sup>F]-fluorocyclobutane-1-carboxylic acid ([<sup>18</sup>F]FACBC) were allowed for routine clinical use in July 2024. However, phantom test procedures for [<sup>18</sup>F]FACBC reconstruction parameters have not yet been established. The present study aimed to establish new phantom test procedures for [<sup>18</sup>F]FACBC brain PET imaging to determine optimal reconstruction parameters.</p><p><strong>Methods: </strong>Background (BG) activity as well as hot sphere and target-to-background ratios (TBRs) of [<sup>18</sup>F]FACBC were estimated based on brain activity and tumor-to-normal tissue ratios (TNR) in a Japanese clinical trial of [<sup>18</sup>F]FACBC. Phantom experiments proceeded under [<sup>18</sup>F]FACBC or L-[methyl-<sup>11</sup>C]-methionine ([<sup>11</sup>C]MET) conditions. The number of iterations and the Gaussian filter parameters were determined from the reconstruction parameters %contrast<sub>mean</sub> and coefficients of variation (CVs) in ordered subset expectation maximization (OSEM) and time-of-flight (TOF) with or without point-spread-function (PSF) correction.</p><p><strong>Results: </strong>The amounts of activity in the hot spheres and BG were 1.1 and 5.5 kBq/mL, respectively, and the TBR was 5.0 at the start of acquisition. The %contrast<sub>mean</sub> of all hot spheres was higher with [<sup>18</sup>F]FACBC than [<sup>11</sup>C]MET, and %contrast<sub>mean</sub> converged between 4 and 6 iterations in hot spheres with diameters < 10 mm. We used four iterations for OSEM + TOF and five for OSEM + TOF + PSF correction for [<sup>18</sup>F]FACBC and [<sup>11</sup>C]MET images. The CV was higher for [<sup>18</sup>F]FACBC than [<sup>11</sup>C]MET. The optimal sizes of Gaussian filters for OSEM + TOF and OSEM + TOF + PSF correction of image reconstruction were 5 mm for [<sup>18</sup>F]FACBC, and 4 and 3 mm, respectively, for [<sup>11</sup>C]MET images.</p><p><strong>Conclusions: </strong>We estimated phantom activity and TBR based on brain activity in a Japanese clinical trial and established new phantom test procedures for [<sup>18</sup>F]FACBC. We recommend that the optimal reconstruction parameters for [<sup>18</sup>F]FACBC should be set to the same number of iterations as [<sup>11</sup>C]MET and that the FWHM of Gaussian filter should have a few mm higher than [<sup>11</sup>C]MET to reduce image noise from brain normal tissue.</p>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12149-024-01973-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12149-024-01973-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Phantom test procedures for a new neuro-oncological amino acid PET tracer: [18F]fluciclovine.
Objective: Amino acid positron emission tomography (PET) examinations using anti-1-amino-3-[18F]-fluorocyclobutane-1-carboxylic acid ([18F]FACBC) were allowed for routine clinical use in July 2024. However, phantom test procedures for [18F]FACBC reconstruction parameters have not yet been established. The present study aimed to establish new phantom test procedures for [18F]FACBC brain PET imaging to determine optimal reconstruction parameters.
Methods: Background (BG) activity as well as hot sphere and target-to-background ratios (TBRs) of [18F]FACBC were estimated based on brain activity and tumor-to-normal tissue ratios (TNR) in a Japanese clinical trial of [18F]FACBC. Phantom experiments proceeded under [18F]FACBC or L-[methyl-11C]-methionine ([11C]MET) conditions. The number of iterations and the Gaussian filter parameters were determined from the reconstruction parameters %contrastmean and coefficients of variation (CVs) in ordered subset expectation maximization (OSEM) and time-of-flight (TOF) with or without point-spread-function (PSF) correction.
Results: The amounts of activity in the hot spheres and BG were 1.1 and 5.5 kBq/mL, respectively, and the TBR was 5.0 at the start of acquisition. The %contrastmean of all hot spheres was higher with [18F]FACBC than [11C]MET, and %contrastmean converged between 4 and 6 iterations in hot spheres with diameters < 10 mm. We used four iterations for OSEM + TOF and five for OSEM + TOF + PSF correction for [18F]FACBC and [11C]MET images. The CV was higher for [18F]FACBC than [11C]MET. The optimal sizes of Gaussian filters for OSEM + TOF and OSEM + TOF + PSF correction of image reconstruction were 5 mm for [18F]FACBC, and 4 and 3 mm, respectively, for [11C]MET images.
Conclusions: We estimated phantom activity and TBR based on brain activity in a Japanese clinical trial and established new phantom test procedures for [18F]FACBC. We recommend that the optimal reconstruction parameters for [18F]FACBC should be set to the same number of iterations as [11C]MET and that the FWHM of Gaussian filter should have a few mm higher than [11C]MET to reduce image noise from brain normal tissue.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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