自闭症患者杏仁核的静息状态功能连接性:一项预先登记的大规模研究。

IF 15.1 1区 医学 Q1 PSYCHIATRY
American Journal of Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI:10.1176/appi.ajp.20230249
Dorit Kliemann, Paola Galdi, Avery L Van De Water, Brandon Egger, Dorota Jarecka, Ralph Adolphs, Satrajit S Ghosh
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引用次数: 0

摘要

目的:关于自闭症谱系障碍(ASD)的三个主要神经生物学假说提出了大脑区域之间连接性不足、杏仁核功能不典型以及自闭症谱系障碍患者之间的变异性普遍高于神经畸形患者之间的变异性。由于样本量小、数据质量未量化以及分析灵活性等原因,以往的研究往往无法推广。本研究在测试上述三个假设的同时,也解决了这些局限性,并将其应用于杏仁核功能连接:在一项预先登记的综合研究中,作者在自闭症脑成像数据交换数据集的一个子集(排除后为488人,其中212人患有自闭症)中对上述三个假设进行了测试。作者分析了来自两个解剖学定义的杏仁核分区的功能磁共振成像数据的静息态功能连通性(FC),在从全脑到特定区域和网络的不同解剖学尺度上,分析了三种假设的幅度、模式相似性和变异性:贝叶斯假设评估方法得出的证据表明,ASD患者的杏仁核FC幅度不典型,但有强有力的证据表明FC的多变量模式是典型的,而且没有一致的证据表明FC的个体间变异性增加。结果在很大程度上取决于分析选择,包括神经影像数据的预处理管道、解剖特异性和排除对象:结论:一组预先登记的分析结果显示,没有可靠证据表明自闭症患者杏仁核存在非典型功能连接,这与主要假设相反。未来的研究应在多个处理管道中测试更多的假设,收集每个个体更深入的数据,并纳入更多样化的参与者,以确保自闭症患者杏仁核功能连接的研究结果具有强大的普遍性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resting-State Functional Connectivity of the Amygdala in Autism: A Preregistered Large-Scale Study.

Objective: Three leading neurobiological hypotheses about autism spectrum disorder (ASD) propose underconnectivity between brain regions, atypical function of the amygdala, and generally higher variability between individuals with ASD than between neurotypical individuals. Past work has often failed to generalize, because of small sample sizes, unquantified data quality, and analytic flexibility. This study addressed these limitations while testing the above three hypotheses, applied to amygdala functional connectivity.

Methods: In a comprehensive preregistered study, the three hypotheses were tested in a subset (N=488 after exclusions; N=212 with ASD) of the Autism Brain Imaging Data Exchange data sets. The authors analyzed resting-state functional connectivity (FC) from functional MRI data from two anatomically defined amygdala subdivisions, in three hypotheses with respect to magnitude, pattern similarity, and variability, across different anatomical scales ranging from whole brain to specific regions and networks.

Results: A Bayesian approach to hypothesis evaluation produced inconsistent evidence in ASD for atypical amygdala FC magnitude, strong evidence that the multivariate pattern of FC was typical, and no consistent evidence of increased interindividual variability in FC. The results strongly depended on analytic choices, including preprocessing pipeline for the neuroimaging data, anatomical specificity, and subject exclusions.

Conclusions: A preregistered set of analyses found no reliable evidence for atypical functional connectivity of the amygdala in autism, contrary to leading hypotheses. Future studies should test an expanded set of hypotheses across multiple processing pipelines, collect deeper data per individual, and include a greater diversity of participants to ensure robust generalizability of findings on amygdala FC in ASD.

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来源期刊
American Journal of Psychiatry
American Journal of Psychiatry 医学-精神病学
CiteScore
22.30
自引率
2.80%
发文量
157
审稿时长
4-8 weeks
期刊介绍: The American Journal of Psychiatry, dedicated to keeping psychiatry vibrant and relevant, publishes the latest advances in the diagnosis and treatment of mental illness. The journal covers the full spectrum of issues related to mental health diagnoses and treatment, presenting original articles on new developments in diagnosis, treatment, neuroscience, and patient populations.
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