动物植入双轴驱动人工肛门括约肌后的肠压研究

IF 3 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Fangfang Hua, Guozheng Yan, Lichao Wang, Tong Wu
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引用次数: 0

摘要

大便失禁(FI)是指无法控制固体、液体或气体粪便的渗漏,人工肛门括约肌(AAS)是除肠造口术外,大便失禁患者最后的选择。为了提高人工肛门括约肌的临床应用价值,检测和分析肠道压力信息是非常必要的。双轴驱动人工肛门括约肌(BAAS)是一种新型的人工肛门括约肌,不仅具有稳定、长期和安全的能量供应,还能实时反馈肠压信息。本文将 BAAS 植入仔猪体内进行长期动物实验。对仔猪的生活习性、排便习惯和肠压进行了分析。分析结果表明,BAAS 系统具有良好的粪便控制效果,当 BAAS 系统执行器关闭时,仔猪基本无粪便渗漏;当 BAAS 系统执行器打开时,仔猪可正常排便。在仔猪健康状况和 BAAS 工作状态正常的情况下,排便感知的准确率达到 65.79%。该研究实现了对仔猪排便机理的深入研究,为新一代自动排便系统的开发提供了指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Study on Intestinal Pressure after Implantation of Biaxial Actuated Artificial Anal Sphincter in Animal

Study on Intestinal Pressure after Implantation of Biaxial Actuated Artificial Anal Sphincter in Animal

Fecal incontinence (FI) referred to the inability to control the leakage of solid, liquid, or gaseous feces, the artificial anal sphincter (AAS) was the last resort for patients with FI except enterostomy. In order to the clinical application value of AAS was improved, the detection and analysis of intestinal pressure information was very necessary. Biaxial actuated artificial anal sphincter (BAAS) was a new type of AAS, which not only had a stable, long-term and safe energy supply, but also could provide real-time feedback of intestinal pressure information. In this paper, the BAAS was implanted into piglets for a long-term animal experiment. Piglets’ life habits, defecation habits and intestinal pressure were analyzed. The analysis results showed that the BAAS system had good feces control effect, when the actuator of the BAAS system was closed, there was basically no fecal leakage of piglets, and when the actuator of the BAAS system was opened, the piglets could defecate normally. Under the normal condition of the piglets’ health state and the BAAS’s operating state, the accuracy of the defecation perception reached to 65.79%. This study realized the in-depth study of the mechanism of piglets’ defecation, and provided guidance for the development of a new generation of AAS.

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来源期刊
Biomedical Microdevices
Biomedical Microdevices 工程技术-工程:生物医学
CiteScore
6.90
自引率
3.60%
发文量
32
审稿时长
6 months
期刊介绍: Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.
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