Degradation pathways of sulfamethoxazole under phototransformation processes: A data base of the major transformation products for their environmental monitoring

Sulfamethoxazole (SMX) is frequently detected in wastewater and aquatic environments worldwide at concentrations from ng L⁻¹ to μg L⁻¹. Unfortunately, SMX is not completely removed in municipal wastewater treatment plants (WWTPs), thus, SMX and their transformation products (TPs) are discharged into aquatic environments, where can be transformed by phototransformation reactions. In this study, the phototransformation of SMX as well as generation of their major TPs under photolysis and photocatalysis processes was reviewed. SMX can be totally removed under photolysis and photocatalysis processes in aqueous solutions using simulated or natural radiation. Degradation pathways such as isomerization, hydroxylation, fragmentation, nitration, and substitution reactions were identified during the generation of the major TPs of SMX. Particularly, 26 TPs were considered for the creation of a data base of the major TPs of SMX generated under phototransformation processes. These 26 compounds could be used as reference during the SMX monitoring both wastewater and water bodies, using analytic methodologies such as target analysis and suspect screening. A data base of the major TPs of pharmaceuticals active compounds (PhACs) as SMX could help to implementation of best environmental monitoring programs for the study of the environmental risks both PhACs and their TPs with highest occurrence in aquatic environments.