Yanzhi Dong, Gang Shu, Yibo Wei, Jinbin Pan, Dong Li, Shao-Kai Sun
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引用次数: 0
摘要
钽(Ta)具有较高的 X 射线衰减系数和良好的生物相容性,是一种很有前景的先进计算机断层扫描(CT)成像探针元素。然而,通过简单的方法合成肾脏透明的钽基成像探针仍是一项重大挑战。在此,我们介绍了一种简单的、克级规模的方法,用于合成具有高水溶性的肾脏透明 Ta 纳米点,用于体内 CT 成像。Ta 纳米点(配位聚合物)是通过 Ta(OH)5、柠檬酸(CA)和过氧化氢的配位反应制成的。Ta 纳米点具有超小水动力直径(2.8 nm)、高水溶性(1.88 g/mL,688 mg Ta/mL)、优异的 X 射线吸收能力、克级生产能力(实验室合成为 10 g)、肾脏可清除能力和良好的生物相容性。Ta 纳米点在不同的管电压下具有卓越的 CT 成像效果,可进行高灵敏度的胃肠道 CT 成像、肾脏 CT 成像和 CT 血管造影 (CTA)。此外,Ta 纳米点即使在高 X 射线能量下也能保持强大的 CT 成像能力,基于 Ta 纳米点的光谱 CT 实现了金属伪影最小化的 CTA。所提出的 Ta 纳米点作为诊断各种疾病的强大 CT 成像探针具有巨大的潜力。
Gram-Scale Synthesis of Renal-Clearable Tantalum Nanodots with High Water Solubility for Computed Tomography Imaging In Vivo
Tantalum (Ta) emerges as a promising element for advanced computed tomography (CT) imaging probes owing to its high X-ray attenuation coefficient and excellent biocompatibility. Nevertheless, the synthesis of renally clear Ta-based imaging probes through simple methods remains a significant challenge. Herein, we introduce a simple and gram-scale approach for the synthesis of renal-clearable Ta nanodots with high water solubility for CT imaging in vivo. The Ta nanodots, coordination polymers, are fabricated via coordination reactions involving Ta(OH)5, citric acid (CA), and hydrogen peroxide. The Ta nanodots exhibit an ultrasmall hydrodynamic diameter (2.8 nm), high water solubility (1.88 g/mL, 688 mg Ta/mL), superior X-ray absorption capacity, gram-scale production capability (>10 g in lab synthesis), renal-clearable ability, and good biocompatibility. The Ta nanodots possess superior CT imaging efficacy across diverse tube voltages, enabling highly sensitive gastrointestinal CT imaging, renal CT imaging, and CT angiography (CTA). Moreover, Ta nanodots maintain robust CT imaging capabilities even at high X-ray energies, and Ta nanodots-based spectral CT achieves metallic artifacts-minimized CTA. The proposed Ta nanodots present substantial potential as a potent CT imaging probe for diagnosing various diseases.
期刊介绍:
ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.